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A meta-analysis of left ventricular dysfunction in ankylosing spondylitis.
Bolaji, Olayiwola; Oriaifo, Osejie; Adabale, Olanrewaju; Dilibe, Arthur; Kuruvada, Krishna; Ouedraogo, Faizal; Ezeh, Ebubechukwu; Nair, Ambica; Olanipekun, Titilope; Mazimba, Sula; Alraies, Chadi.
Afiliación
  • Bolaji O; Department of Internal Medicine, Rutgers University New Jersey Medical School, Newark, New Jersey, USA.
  • Oriaifo O; Department of Internal Medicine, ECU Health Medical Center, Greenville, North Carolina, USA.
  • Adabale O; Department of Internal Medicine, ECU Health Medical Center, Greenville, North Carolina, USA.
  • Dilibe A; Department of Internal Medicine, ECU Health Medical Center, Greenville, North Carolina, USA.
  • Kuruvada K; Department of Internal Medicine, University of Maryland Capital Region Health, Largo, Maryland, USA.
  • Ouedraogo F; Department of Internal Medicine, University of Maryland Capital Region Health, Largo, Maryland, USA.
  • Ezeh E; Department of Cardiovascular Disease, The University Of Kansas Medical Center, Kansas City, Kansas, USA.
  • Nair A; Ocean Medical Center Brick, Brick, New Jersey, USA.
  • Olanipekun T; Brigham and Women's Hospital Department of Medicine Boston, Boston, Massachusetts, USA.
  • Mazimba S; Advanced Heart Failure and Transplant Cardiology, AdventHealth Medical Group Transplant Institute, Orlando, Florida, USA.
  • Alraies C; Cardiovascular Institute, Detroit Medical Center, DMC Heart Hospital, Detroit, Michigan, USA.
J Clin Hypertens (Greenwich) ; 26(7): 772-788, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38708932
ABSTRACT
Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting the spine, presenting a considerable morbidity risk. Although evidence consistently indicates an elevated risk of ischemic heart disease among AS patients, debates persist regarding the likelihood of these patients developing left ventricular dysfunction (LVD). Our investigation aimed to determine whether individuals with AS face a greater risk of LVD compared to the general population. To accomplish this, we identified studies exploring LVD in AS patients across five major databases and Google Scholar. Initially, 431 studies were identified, of which 30 met the inclusion criteria, collectively involving 2933 participants. Results show that AS patients had (1) poorer Ejection Fraction (EF) [mean difference (MD) -0.92% (95% CI -1.25 to -0.59)], (2) impaired Early (E) and Late (atrial-A) ventricular filling velocity (E/A) ratio [MD -0.10 m/s (95% CI -0.13 to -0.08)], (3) prolonged deceleration time (DT) [MD 12.30 ms (95% CI 9.23-15.36)] and, (4) a longer mean isovolumetric relaxation time (IVRT) [MD 8.14 ms (95% CI 6.58-9.70)] compared to controls. Though AS patients show increased risks of both systolic and diastolic LVD, we found no significant differences were observed in systolic blood pressure [MD 0.32 mmHg (95% Confidence Interval (CI) -2.09 to 2.73)] or diastolic blood pressure [MD 0.30 mmHg (95% CI -0.40 to 1.01)] compared to the general population. This study reinforces AS patients' susceptibility to LVD without a notable difference in HTN risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Volumen Sistólico / Disfunción Ventricular Izquierda Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Hypertens (Greenwich) Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Volumen Sistólico / Disfunción Ventricular Izquierda Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Hypertens (Greenwich) Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos