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Nanoassembly-Mediated Exendin-4 Derivatives to Decrease Renal Retention.
Zhou, Zhengwei; Wang, Shuai; Feng, Tianling; Zhang, Pengjun; Fan, Hongwei; Zou, Jianjun; Huang, Kaizong.
Afiliación
  • Zhou Z; Department of Clinical Pharmacology Lab, Nanjing First Hospital, Nanjing Medical University, Changle Road 68, Nanjing 210006, P. R. China.
  • Wang S; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 210009, P. R. China.
  • Feng T; Department of Clinical Pharmacology Lab, Nanjing First Hospital, Nanjing Medical University, Changle Road 68, Nanjing 210006, P. R. China.
  • Zhang P; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 210009, P. R. China.
  • Fan H; Department of Clinical Pharmacology Lab, Nanjing First Hospital, Nanjing Medical University, Changle Road 68, Nanjing 210006, P. R. China.
  • Zou J; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 210009, P. R. China.
  • Huang K; Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Changle Road 68, Nanjing 210006, P. R. China.
ACS Omega ; 9(17): 18757-18765, 2024 Apr 30.
Article en En | MEDLINE | ID: mdl-38708210
ABSTRACT
An Exendin-4 analogue that was conjugated with 68Ga exhibited an excellent diagnostic effect on insulinoma in clinical practice. On account of its low molecular weight and short hydration radius, 68Ga-Exendin-4 showed high accumulation in kidney tissues. Nanoparticle-mediated strategies have attracted much attention due to polyvalent properties and the size amplification effect. In this study, Exendin-4 derivatives of radionuclide nanodevices were developed and evaluated. The Exendin-4 derivatives consisting of a ternary block recombinant protein were purified by an inverse transition cycle (ITC) and allowed to self-assemble into a nanodevice under physiological conditions. Our results showed that the nanoassemblies of Exendin-4 derivatives formed homogeneous spherical nanoparticles, exhibited outstanding affinity for insulinoma cells, and could be deposited in insulinoma tissues in vivo. The nanoassembly-mediated Exendin-4 derivatives showed fivefold reduced renal retention and exhibited an outstanding tumor-suppression effect.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Omega Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Omega Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos