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The Sensitization Differences of Pollen Allergen Components in Patients with Asthma and/or Rhinitis in Southern China.
Xu, Chun; Chai, Dandan; Zheng, Ping; Qiu, Rongjun; Pan, Xiaocong; Zhang, Yaqiong.
Afiliación
  • Xu C; Jiangxi Medical College, Shangrao, China.
  • Chai D; Department of Clinical laboratory, The First Affiliated Hospital of Jiangxi Medical College, Shangrao, China.
  • Zheng P; Department of Clinical laboratory, ShangRao People's Hospital, Shangrao, China.
  • Qiu R; Department of Urology, Shangrao Municipal Hospital, Shangrao, China.
  • Pan X; Department of Clinical laboratory, ShangRao People's Hospital, Shangrao, China.
  • Zhang Y; Guangzhou Medical University, Guangzhou, China, 2425693823@qq.com.
Int Arch Allergy Immunol ; 185(9): 821-826, 2024.
Article en En | MEDLINE | ID: mdl-38705139
ABSTRACT

INTRODUCTION:

This study aim to analyzed the main pollen allergen components that cause allergic asthma and/or rhinitis and the cross-reactions between the allergen components.

METHODS:

Twenty one allergic rhinitis patients and 23 allergic asthma patients with pollen sensitization from the China Biological Information Repository of Respiratory Diseases were included. All the patients were detected serum pollen allergens components specific immunoglobulin E (sIgE) including Betula verrucosa (Bet v 1, Bet v 2, Bet v 4), Quercus alba (Pla a 1, Pla a 2), Ambrosia elatior (Amb a 1), Artemisia vulgaris (Art v 1, Art v 3, Art v 4), Bermuda grass (Cyn d 1, Cyn d 12), Phleum pratense (Phl p 5, Phl p 1, Phl p 4, Phl p 7, Phl p 12), and cross-reactive carbohydrate determinants.

RESULTS:

In patients with asthma, Phl p 4 had the highest positive rate (60.9%), followed by Phl p 1 (43.5%) and Pla a 2 (34.8%), while in patients with rhinitis, Amb a 1 had the highest positive rate (71.4%), followed by Phl p 4 (61.9%) and Pla a 2 (42.9%). Meanwhile, Phl p 1 (43.5%) in asthma patients was higher than that in rhinitis (4.7%, p = 0.03), while Amb a 1 (71.4%) in rhinitis patients was higher than that in asthma (26.1%, p = 0.03). Interestingly, optimal scale analysis show that the severity of both asthma and rhinitis is related to Bet v 4 (Cronbach's Alpha = 95.0%).

CONCLUSIONS:

In general, Phl p 4 is the main allergenic component in pollen sensitized asthma patients, while Amb a 1 is the main allergenic component in pollen sensitized rhinitis patients. Sensitization to Bet v 4 may lead to more severe symptoms, and this result may be applied in future clinical precise diagnosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polen / Asma / Inmunoglobulina E / Alérgenos / Rinitis Alérgica Estacional / Reacciones Cruzadas Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Int Arch Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polen / Asma / Inmunoglobulina E / Alérgenos / Rinitis Alérgica Estacional / Reacciones Cruzadas Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Int Arch Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza