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Predicted concentrations of antineoplastic drugs in the aquatic environment: The case of Ría de Vigo (NW, Spain).
Couñago-Fernández, Moisés; Otero, Pablo; Samartín-Ucha, Marisol; Paradela-Carreiro, Adolfo; Muniategui-Lorenzo, Soledad; Martínez-López de Castro, Noemí.
Afiliación
  • Couñago-Fernández M; Pharmacy Service, Complexo Hospitalario Universitario de Vigo, Área Sanitaria de Vigo, Spain. Electronic address: moises.counago.fernandez@sergas.es.
  • Otero P; Centro Oceanográfico de Vigo, Instituto Español de Oceanografía (IEO, CSIC), Subida a Radio Faro 50, Vigo 36390, Spain.
  • Samartín-Ucha M; Pharmacy Service, Complexo Hospitalario Universitario de Vigo, Área Sanitaria de Vigo, Spain; Innovation in Clinical Pharmacy Research Group (i-FARMA-Vigo), Galicia Sur Health Research Institute (IIS Galicia Sur) SERGAS-UVIGO, Vigo, Spain.
  • Paradela-Carreiro A; Pharmacy Service, Complexo Hospitalario Universitario de Vigo, Área Sanitaria de Vigo, Spain; Innovation in Clinical Pharmacy Research Group (i-FARMA-Vigo), Galicia Sur Health Research Institute (IIS Galicia Sur) SERGAS-UVIGO, Vigo, Spain.
  • Muniategui-Lorenzo S; University of A Coruña, Group of Applied Analytical Chemistry, University Institute of Environment (IUMA), A Coruña 15071, Spain.
  • Martínez-López de Castro N; Pharmacy Service, Complexo Hospitalario Universitario de Vigo, Área Sanitaria de Vigo, Spain; Innovation in Clinical Pharmacy Research Group (i-FARMA-Vigo), Galicia Sur Health Research Institute (IIS Galicia Sur) SERGAS-UVIGO, Vigo, Spain.
Mar Pollut Bull ; 203: 116399, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38703630
ABSTRACT
The European Medicines Agency (EMA) mandates Environmental Risk Assessments (ERAs) since 2006 to determine potential risks of new marketed medicines. Drugs with a Predicted Environmental Concentration (PEC) in inland surface waters exceeding 0.01 µg L-1 require further environmental risk assessment. PEC may be refined based on prevalence data and/or based on the treatment regimen. In this study, based on EMA regulations, refined PEC of 108 antineoplastic drugs in coastal waters were determined based on the consumption in a coastal health area during 2021, identifying six drugs with potential environmental risk in surface waters (hydroxyurea, capecitabine, abiraterone, ibrutinib, imatinib and 5-fluorouracil) and two in marine ecosystem (hydroxyurea and capecitabine). Comparison of these refined PECs with data from marketing laboratories revealed significant disparities, suggesting the need for regular updates, especially with changes in drug indications or financing. Notably, the identified drugs are not yet on the main reference lists of emerging contaminants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Monitoreo del Ambiente / Antineoplásicos País/Región como asunto: Europa Idioma: En Revista: Mar Pollut Bull Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Monitoreo del Ambiente / Antineoplásicos País/Región como asunto: Europa Idioma: En Revista: Mar Pollut Bull Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido