The immune interactions of gut glycans and microbiota in health and disease.

Demirturk, Mahmut; Cinar, Mukaddes Sena; Avci, Fikri Y

Demirturk, Mahmut; Cinar, Mukaddes Sena; Avci, Fikri Y.

Afiliación

Demirturk M; Department of Biochemistry, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Cinar MS; Department of Biochemistry, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Avci FY; Department of Biochemistry, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.

Mol Microbiol ; 2024 May 04.

Article en En | MEDLINE | ID: mdl-38703041

ABSTRACT

ABSTRACT

The human digestive system harbors a vast diversity of commensal bacteria and maintains a symbiotic relationship with them. However, imbalances in the gut microbiota accompany various diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancers (CRCs), which significantly impact the well-being of populations globally. Glycosylation of the mucus layer is a crucial factor that plays a critical role in maintaining the homeostatic environment in the gut. This review delves into how the gut microbiota, immune cells, and gut mucus layer work together to establish a balanced gut environment. Specifically, the role of glycosylation in regulating immune cell responses and mucus metabolism in this process is examined.

Palabras clave

MUC2; gut immunity; gut microbiota; gut mucosa; inflammatory bowel diseases; mucin glycosylation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Microbiol Asunto de la revista: BIOLOGIA MOLECULAR / MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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