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Associations between Physical Activity and the Incidence of Cerebrovascular Disease or All-Cause Mortality among 146,742 Older Adults: A 13-Year Prospective Cohort Study.
Yang, Qi-Hao; Zhang, Yong-Hui; Lok Wong, Arnold Yu; Xu, Hao-Ran; Bi, Xia; Ching, Yuen Lim; Du, Shu-Hao; Wang, Yu-Chen; Wang, Xue-Qiang.
Afiliación
  • Yang QH; Department of Rehabilitation Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China; Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences
  • Zhang YH; Department of Rehabilitation Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China; School of Rehabilitation Medicine, We
  • Lok Wong AY; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China.
  • Xu HR; Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
  • Bi X; Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
  • Ching YL; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
  • Du SH; Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
  • Wang YC; Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
  • Wang XQ; Department of Rehabilitation Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China; Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences
J Am Med Dir Assoc ; 25(7): 105010, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38702045
ABSTRACT

OBJECTIVES:

Although studies have indicated that physical activity (PA) is related to cardiovascular disease, the specific association between PA and incident cerebrovascular disease (CBVD) remains uncertain. The current study aimed to investigate the associations between PA levels and the CBVD incidence or all-cause mortality.

DESIGN:

Prospective cohort study. SETTINGS AND

PARTICIPANTS:

Older participants (aged >60 years) from the UK Biobank.

METHODS:

The baseline PA was classified as total, light, moderate, and vigorous PA based on the metabolic equivalent-minutes per week (MET-min/wk) and considered as exposures, whereas CBVD incidence and all-cause mortality were considered as the outcomes. Cox proportional hazards were used to calculate the hazard ratios (HRs) and 95% CIs for the influence of the association between PA and CBVD incidence and all-cause mortality.

RESULTS:

A total of 146,742 participants aged 60 years and older were included. During a median follow-up period of 13.5 years (interquartile range of 12.8-14.2), 9338 older individuals developed CBVD and 3033 death were recorded (including 767 CBVD-related deaths). High volumes of PA were consistently associated with lower risks of CBVD and all-cause mortality. The lowest risk of CBVD incidence was observed at 2001-2500 MET-min/wk of total PA (HR 0.61, 95% CI 0.53-0.70), and the lowest risk of all-cause mortality was observed at 2501-5000 MET-min/wk (HR 0.52, 95% CI 0.43-0.63) in older adults. Total PA at 2001-2500 MET-min/wk significantly reduced the CBVD incidence in older women (HR 0.57, 95% CI 0.46-0.71), which was more pronounced than that in older men (HR for 2001-2500 MET-min/wk 0.64, 95% CI 0.50-0.77). CONCLUSIONS AND IMPLICATIONS Total PA at 2001-2500 MET-min/wk significantly reduced the risk of incident CBVD and all-cause mortality in adults aged >60 years, although the extents of risk reduction vary in men and women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Trastornos Cerebrovasculares Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Am Med Dir Assoc Asunto de la revista: HISTORIA DA MEDICINA / MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Trastornos Cerebrovasculares Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Am Med Dir Assoc Asunto de la revista: HISTORIA DA MEDICINA / MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos