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SGLT2 inhibitor as a potential therapeutic approach in hyperthyroidism-induced cardiopulmonary injury in rats.
Bastawy, Nermeen; El-Mosallamy, Aliaa E M K; Aljuaydi, Samira H; AbuBakr, Huda O; Rasheed, Rabab Ahmed; Sadek, A S; Khattab, R T; Abualyamin, Wael Botros; Abdelaal, Shereen E; Boushra, Amy F.
Afiliación
  • Bastawy N; Department of Medical Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • El-Mosallamy AEMK; Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.
  • Aljuaydi SH; Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
  • AbuBakr HO; Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
  • Rasheed RA; Department of Biochemistry, Faculty of Veterinary Medicine, Egyptian Chinese University, Cairo, Egypt.
  • Sadek AS; Department of Medical Histology and Cell Biology, Faculty of Medicine, King Salman International University, El Tor, 46511, South Sinai, Egypt. rabab.rasheed@ksiu.edu.eg.
  • Khattab RT; Department of Anatomy and Embryology, Faculty of Medicine, Ain Shams University, Cairo, 11566, Egypt.
  • Abualyamin WB; Department of Anatomy and Embryology, Faculty of Medicine, King Salman International University, El Tor, 46511, South Sinai, Egypt.
  • Abdelaal SE; Department of Anatomy and Embryology, Faculty of Medicine, Ain Shams University, Cairo, 11566, Egypt.
  • Boushra AF; Department of Medical Physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Pflugers Arch ; 476(7): 1125-1143, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38700719
ABSTRACT
Hyperthyroidism-induced cardiac disease is an evolving health, economic, and social problem affecting well-being. Sodium-glucose cotransporter protein 2 inhibitors (SGLT2-I) have been proven to be cardio-protective when administered in cases of heart failure. This study intended to investigate the potential therapeutic effect of SGLT2-I on hyperthyroidism-related cardiopulmonary injury, targeting the possible underlying mechanisms. The impact of the SGLT2-I, dapagliflozin (DAPA), (1 mg/kg/day, p.o) on LT4 (0.3 mg/kg/day, i.p)-induced cardiopulmonary injury was investigated in rats. The body weight, ECG, and serum hormones were evaluated. Also, redox balance, DNA fragmentation, inflammatory cytokines, and PCR quantification in heart and lung tissues were employed to investigate the effect of DAPA in experimentally induced hyperthyroid rats along with histological and immunohistochemical examination. Coadministration of DAPA with LT4 effectively restored all serum biomarkers to nearly average levels, improved ECG findings, and reinstated the redox balance. Also, DAPA could improve DNA fragmentation, elevate mtTFA, and lessen TNF-α and IGF-1 gene expression in both organs of treated animals. Furthermore, DAPA markedly improved the necro-inflammatory and fibrotic cardiopulmonary histological alterations and reduced the tissue immunohistochemical expression of TNF-α and caspase-3. Although further clinical and deep molecular studies are required before transposing to humans, our study emphasized DAPA's potential to relieve hyperthyroidism-induced cardiopulmonary injury in rats through its antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as via antagonizing the sympathetic over activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Bencidrilo / Inhibidores del Cotransportador de Sodio-Glucosa 2 / Glucósidos / Hipertiroidismo Límite: Animals Idioma: En Revista: Pflugers Arch Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Bencidrilo / Inhibidores del Cotransportador de Sodio-Glucosa 2 / Glucósidos / Hipertiroidismo Límite: Animals Idioma: En Revista: Pflugers Arch Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Alemania