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NKG2C+CD57+ natural killer cells with senescent features are induced during cutaneous leishmaniasis and accumulate in patients with lesional healing impairment.
Covre, Luciana Polaco; Fantecelle, Carlos Henrique; Queiroz, Ariadne Mendes; Fardin, Julia Miranda; Miranda, Pedro Henrique; Henson, Sian; Fonseca-Martins, Alessandra Marcia da; de Matos Guedes, Herbert Leonel; Mosser, David; Falqueto, Aloisio; Akbar, Arne; Gomes, Daniel Claudio Oliveira.
Afiliación
  • Covre LP; Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.
  • Fantecelle CH; Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Queiroz AM; Division of Medicine, University College London, London, UK.
  • Fardin JM; Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.
  • Miranda PH; Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.
  • Henson S; Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.
  • Fonseca-Martins AMD; Núcleo de Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Brazil.
  • de Matos Guedes HL; Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Mosser D; Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Falqueto A; Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Akbar A; Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Gomes DCO; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Clin Exp Immunol ; 217(3): 279-290, 2024 Aug 09.
Article en En | MEDLINE | ID: mdl-38700066
ABSTRACT
Natural killer (NK) cells include different subsets with diverse effector capacities that are poorly understood in the context of parasitic diseases. Here, we investigated inhibitory and activating receptor expression on NK cells in patients with cutaneous leishmaniasis (CL) and explored their phenotypic and functional heterogeneity based on CD57 and NKG2C expression. The expression of CD57 identified NK cells that accumulated in CL patients and exhibited features of senescence. The CD57+ cells exhibited heightened levels of the activating receptor NKG2C and diminished expression of the inhibitory receptor NKG2A. RNA sequencing analyses based on NKG2C transcriptome have revealed two distinct profiles among CL patients associated with cytotoxic and functional genes. The CD57+NKG2C+ subset accumulated in the blood of patients and presented conspicuous features of senescence, including the expression of markers such as p16, yH2ax, and p38, as well as reduced proliferative capacity. In addition, they positively correlated with the number of days until lesion resolution. This study provides a broad understanding of the NK cell biology during Leishmania infection and reinforces the role of senescent cells in the adverse clinical outcomes of CL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Leishmaniasis Cutánea / Senescencia Celular / Antígenos CD57 / Subfamília C de Receptores Similares a Lectina de Células NK Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Exp Immunol Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Leishmaniasis Cutánea / Senescencia Celular / Antígenos CD57 / Subfamília C de Receptores Similares a Lectina de Células NK Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Exp Immunol Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido