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Bafi A1 inhibits nano-copper oxide-induced mitochondrial damage by reducing the release of copper from lysosomes.
Huang, Zhi; Lin, Mo; Wang, Lei; Dou, Liangding; Hou, Xin; Zhang, Jinwen; Huang, Yongchao; Wei, Lifang; An, Ran; Wang, Dai; Yao, Youliang; Guo, Dongbei; Li, Zhibo; Zhang, Yongxing.
Afiliación
  • Huang Z; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
  • Lin M; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
  • Wang L; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
  • Dou L; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
  • Hou X; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
  • Zhang J; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
  • Huang Y; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
  • Wei L; Department of Nephrology, Third People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China.
  • An R; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
  • Wang D; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
  • Yao Y; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
  • Guo D; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
  • Li Z; The 5th Ward, Department of Internal Medicine, Anshan Tuberculosis Hospital, Anshan, China.
  • Zhang Y; State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen,
J Appl Toxicol ; 44(8): 1257-1268, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38700028
ABSTRACT
This study demonstrated that both copper oxide nanoparticles (CuO-NPs) and copper nanoparticles (Cu-NPs) can cause swelling, inflammation, and cause damage to the mitochondria of alveolar type II epithelial cells in mice. Cellular examinations indicated that both CuO-NPs and Cu-NPs can reduce cell viability and harm the mitochondria of human bronchial epithelial cells, particularly Beas-2B cells. However, it is clear that CuO-NPs exhibit a more pronounced detrimental effect compared with Cu-NPs. Using bafilomycin A1 (Bafi A1), an inhibitor of lysosomal acidification, was found to enhance cell viability and alleviate mitochondrial damage caused by CuO-NPs. Additionally, Bafi A1 also reduces the accumulation of dihydrolipoamide S-acetyltransferase (DLAT), a marker for mitochondrial protein toxicity, induced by CuO-NPs. This observation suggests that the toxicity of CuO-NPs depends on the distribution of copper particles within cells, a process facilitated by the acidic environment of lysosomes. The release of copper ions is thought to be triggered by the acidic conditions within lysosomes, which aligns with the lysosomal Trojan horse mechanism. However, this association does not seem to be evident with Cu-NPs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Supervivencia Celular / Macrólidos / Cobre / Nanopartículas del Metal / Lisosomas / Mitocondrias Límite: Animals / Humans / Male Idioma: En Revista: J Appl Toxicol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Supervivencia Celular / Macrólidos / Cobre / Nanopartículas del Metal / Lisosomas / Mitocondrias Límite: Animals / Humans / Male Idioma: En Revista: J Appl Toxicol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido