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Expression of nuclear receptor co­activator 7 protein is associated with poor prognosis of breast cancer.
Peng, Ziluo; Li, Yanlin; Xia, Song; Dai, Qian; Yin, Liang; Chen, Miao; Yang, Wannian; Shao, Genbao; Lin, Qiong.
Afiliación
  • Peng Z; School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
  • Li Y; School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
  • Xia S; School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
  • Dai Q; Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
  • Yin L; Department of Breast Surgery, Jiangsu University Affiliated People's Hospital, Zhenjiang, Jiangsu 212050, P.R. China.
  • Chen M; School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
  • Yang W; Department of Pathology, Jiangsu University Affiliated People's Hospital, Zhenjiang, Jiangsu 212050, P.R. China.
  • Shao G; School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
  • Lin Q; School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
Oncol Lett ; 27(6): 278, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38699661
ABSTRACT
Nuclear receptor coactivator 7 (NCOA7) is an estrogen receptor binding protein. Its role in breast cancer progression has so far remained elusive. The present study aimed to determine the expression levels of NCOA7 in breast tumor samples and confirmed its potential utility as a breast cancer prognostic biomarker. The expression of NCOA7 was detected by immunohistochemical staining in 241 breast cancer tumor samples and 163 adjacent normal tissue samples. The association of NCOA7 expression with the clinicopathological characteristics and overall survival were statistically analyzed. Cell proliferation was determined by Cell Counting Kit-8 and colony-formation assays. Cell migration was detected using wound-healing and Transwell assays. NCOA7 was positively expressed in 44% of breast tumor tissues. The expression of NCOA7 was positively associated with tumor size (T-stage; P=0.005) and lymph node metastasis (N-stage; P=0.008). Additional statistical analysis indicated that the expression of NCOA7 was associated with patient age, tumor size and lymph node metastasis in patients with triple-negative breast cancer (TNBC) compared with that in patients with non-TNBC. The overall survival of patients with NCOA7-positive breast cancer was significantly lower than that of patients with NCOA7-negative breast cancer (P=0.006). Among the patients with lymph node metastasis, the overall survival was reversely associated with the expression of NCOA7 (P=0.042). Furthermore, knockdown of NCOA7 expression in breast cancer T47D and MCF7 cells significantly inhibited both cell proliferation and migration, suggesting that this protein may exert a role in driving breast cancer progression. Taken together, these results indicate that the expression of NCOA7 is associated with poor prognosis of breast cancer and suggest that this protein may be a driver for metastasis and a potential therapeutic target for advanced breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncol Lett Año: 2024 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncol Lett Año: 2024 Tipo del documento: Article Pais de publicación: Grecia