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A first comprehensive analysis of Transcribed Ultra Conserved Regions uncovers important regulatory functions of novel non-coding transcripts in gliomas.
Gibert, Myron K; Zhang, Ying; Saha, Shekhar; Marcinkiewicz, Pawel; Dube, Collin; Hudson, Kadie; Sun, Yunan; Bednarek, Sylwia; Chagari, Bilhan; Sarkar, Aditya; Roig-Laboy, Christian; Neace, Natalie; Saoud, Karim; Setiady, Initha; Hanif, Farina; Schiff, David; Kumar, Pankaj; Kefas, Benjamin; Hafner, Markus; Abounader, Roger.
Afiliación
  • Gibert MK; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Zhang Y; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Saha S; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Marcinkiewicz P; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Dube C; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Hudson K; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Sun Y; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Bednarek S; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Chagari B; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Sarkar A; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Roig-Laboy C; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Neace N; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Saoud K; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Setiady I; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Hanif F; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Schiff D; University of Virginia Department of Neurology, Charlottesville, VA, 22908, USA.
  • Kumar P; University of Virginia Department of Public Health Sciences and Bioinformatics Core, Charlottesville, VA, 22908, USA.
  • Kefas B; University of Virginia Department of Microbiology, Immunology & Cancer Biology, Charlottesville, VA, 22908, USA.
  • Hafner M; University of Virginia Department of Neurology, Charlottesville, VA, 22908, USA.
  • Abounader R; University of Virginia Department of Cancer Center, Charlottesville, VA, 22908, USA.
Res Sq ; 2024 Apr 18.
Article en En | MEDLINE | ID: mdl-38699302
ABSTRACT
Transcribed Ultra-Conserved Regions (TUCRs) represent a severely understudied class of putative non-coding RNAs (ncRNAs) that are 100% conserved across multiple species. We performed the first-ever analysis of TUCRs in glioblastoma (GBM) and low-grade gliomas (LGG). We leveraged large human datasets to identify the genomic locations, chromatin accessibility, transcription, differential expression, correlation with survival, and predicted functions of all 481 TUCRs, and identified TUCRs that are relevant to glioma biology. Of these, we investigated the expression, function, and mechanism of action of the most highly upregulated intergenic TUCR, uc.110, identifying it as a new oncogene. Uc.110 was highly overexpressed in GBM and LGG, where it promoted malignancy and tumor growth. Uc.110 activated the WNT pathway by upregulating the expression of membrane frizzled-related protein (MFRP), by sponging the tumor suppressor microRNA miR-544. This pioneering study shows important roles for TUCRs in gliomas and provides an extensive database and novel methods for future TUCR research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Res Sq Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Res Sq Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos