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Early-life nutrition is associated with processing speed at age 5 in children born preterm with very low birth weight.
Bando, Nicole; Sato, Julie; Taylor, Margot J; Tomlinson, Christopher; Unger, Sharon; Asbury, Michelle R; Law, Nicole; O'Connor, Deborah L.
Afiliación
  • Bando N; Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
  • Sato J; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Taylor MJ; Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Tomlinson C; Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Unger S; Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Asbury MR; Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Law N; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
  • O'Connor DL; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.
J Pediatr Gastroenterol Nutr ; 79(1): 140-147, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38698666
ABSTRACT

OBJECTIVE:

Processing speed is suboptimal among preterm-born children which is of concern as it is a foundational skill supporting higher-level cognitive functions. The study objective was to evaluate associations between early-life nutrition and processing speed in childhood.

METHODS:

Macronutrient and human milk (mother's own, donor) intakes from 137 children born preterm with very low birth weight enrolled in a nutrition feeding trial were included. Processing speed was evaluated at age 5 using the Wechsler Preschool and Primary Scale of Intelligence-fourth edition Processing Speed Index. Associations between early-life nutrition and processing speed were explored through linear regression.

RESULTS:

Children had a mean (standard deviation [SD]) birth gestational age of 28.1 (2.5) weeks, weight of 1036 (260) g and 52% were male. The mean (SD) assessment age was 5.7 (0.2) years. Sex-dependent relationships were identified between first postnatal month protein, lipid and energy intakes and processing speed at 5 years. For females, lower protein (per 0.1 g/kg/d -0.88, 95% confidence interval [CI] -1.53, -0.23; p = 0.01) and energy (per 10 kcal/kg/d -2.38, 95% CI -4.70, -0.05; p = 0.03) intakes were related to higher processing speed scores. Mother's milk provision was positively associated (per 10% increase 0.80, 95% CI 0.22, 1.37; p = 0.01) and donor milk was negatively associated (per 10% increase -1.15, 95% CI -2.22, -0.08; p = 0.04) with processing speed scores; no sex differences were observed.

CONCLUSIONS:

First postnatal month nutrition was related to processing speed at age 5 in children born preterm with very low birth weight. Early-life nutrition that supports processing speed may be leveraged to improve later cognitive outcomes for this vulnerable population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Recién Nacido de muy Bajo Peso / Leche Humana Límite: Child, preschool / Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr Gastroenterol Nutr Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Recién Nacido de muy Bajo Peso / Leche Humana Límite: Child, preschool / Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr Gastroenterol Nutr Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos