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Construction of a pectin/sodium alginate composite hydrogel delivery system for improving the bioaccessibility of phycocyanin.
Li, Zhixin; Geng, Yuxin; Bu, Kaixuan; Chen, Zhengtao; Xu, Kang; Zhu, Chuanhe.
Afiliación
  • Li Z; College of Food Science and Engineering, Shandong Agricultural University, Tai'an 271000, PR China.
  • Geng Y; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, No.440, Jiyan Road, Jinan, Shandong Province 250117, PR China.
  • Bu K; College of Food Science and Engineering, Shandong Agricultural University, Tai'an 271000, PR China.
  • Chen Z; School of Laboratory Animal & Shandong Laboratory Animal Center, Shandong First Medical University & Shandong Academy of Medical Sciences, No.6699, Qingdao Road, Jinan, Shandong Province 250117, PR China. Electronic address: ztchen@sdfmu.edu.cn.
  • Xu K; College of Food Science and Engineering, Shandong Agricultural University, Tai'an 271000, PR China. Electronic address: xukang@sdau.edu.cn.
  • Zhu C; College of Food Science and Engineering, Shandong Agricultural University, Tai'an 271000, PR China. Electronic address: chhzhu@sdau.edu.cn.
Int J Biol Macromol ; 269(Pt 2): 131969, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38697419
ABSTRACT
In this study, different concentrations of sodium alginate were compounded with pectin and phycocyanin to co-prepare composite hydrogel spheres (HP-PC-SA 0.2 %, 0.6 %, 1.0 %, 1.4 %) to evaluate the potential of the composite hydrogel spheres for the application as phycocyanin delivery carriers. The hydrogel spheres' physicochemical properties and bioaccessibility were assessed through scanning electron microscopy, textural analysis, drug-carrying properties evaluation, and in vitro and in vivo controlled release analysis in the gastrointestinal environment. Results indicated that higher sodium alginate concentrations led to smaller pore sizes and denser networks on the surface of hydrogel spheres. The textural properties of hydrogel spheres improved, and their water-holding capacity increased from 93.01 % to 97.97 %. The HP-PC-SA (1.0 %) formulation achieved the highest encapsulation rate and drug loading capacity, at 96.87 % and 6.22 %, respectively. Within the gastrointestinal tract, the composite hydrogel's structure significantly enhanced and protected the phycocyanin's digestibility, achieving a bioaccessibility of up to 88.03 %. In conclusion, our findings offer new insights into improving functionality and the effective use of phycocyanin via pectin-based hydrogel spheres.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ficocianina / Portadores de Fármacos / Pectinas / Hidrogeles / Alginatos Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ficocianina / Portadores de Fármacos / Pectinas / Hidrogeles / Alginatos Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos