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Urinary benzophenone-3 concentrations and ovarian reserve in a cohort of subfertile women.
Silva, Emily L; Mínguez-Alarcón, Lidia; Coull, Brent; Hart, Jaime E; James-Todd, Tamarra; Calafat, Antonia M; Ford, Jennifer B; Hauser, Russ; Mahalingaiah, Shruthi.
Afiliación
  • Silva EL; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Electronic address: emily.luisa.silva@gmail.com.
  • Mínguez-Alarcón L; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  • Coull B; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Hart JE; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  • James-Todd T; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Calafat AM; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Ford JB; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Hauser R; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Mahalingaiah S; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts.
Fertil Steril ; 122(3): 494-503, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38697237
ABSTRACT

OBJECTIVE:

To evaluate the association between the urinary benzophenone-3 concentrations and measures of ovarian reserve (OR) among women in the Environment and Reproductive Health study seeking fertility treatment at Massachusetts General Hospital (MGH) in Boston, Massachusetts.

DESIGN:

Prospective cohort study.

SETTING:

MGH infertility clinic in Boston, Massachusetts. PATIENT(S) Women in the Environment and Reproductive Health cohort seeking fertility treatment. INTERVENTION(S) Women contributed spot urine samples prior to assessment of OR outcomes that were analyzed for benzophenone-3 concentrations. MAIN OUTCOME MEASURE(S) Antral follicle count (AFC) and day 3 follicle-stimulating hormone (FSH) levels were evaluated as part of standard infertility workups during unstimulated menstrual cycles. Quasi-Poisson and linear regression models were used to evaluate the association of the specific gravity-adjusted urinary benzophenone-3 concentrations with AFC and FSH, with adjustment for age and physical activity. In the secondary analyses, models were stratified by age. RESULT(S) This study included 142 women (mean age ± standard deviation, 36.1 ± 4.6 years; range, 22-45 years) enrolled between 2009 and 2017 with both urinary benzophenone-3 and AFC measurements and 57 women with benzophenone-3 and FSH measurements. Most women were White (78%) and highly educated (49% with a graduate degree). Women contributed a mean of 2.7 urine samples (range, 1-10), with 37% contributing ≥2 samples. Benzophenone-3 was detected in 98% of samples. The geometric mean specific gravity-corrected urinary benzophenone-3 concentration was 85.9 µg/L (geometric standard deviation, 6.2). There were no associations of benzophenone-3 with AFC and day 3 FSH in the full cohort. In stratified models, a 1-unit increase in the log geometric mean benzophenone-3 concentration was associated with a 0.91 (95% confidence interval, 0.86-0.97) times lower AFC among women aged ≤35 years and an increase in the FSH concentration of 0.73 (95% confidence interval, 0.12-1.34) IU/L among women aged >35 years. CONCLUSION(S) In the main models, urinary benzophenone-3 was not associated with OR. However, younger patients may be vulnerable to the potential effects of benzophenone-3 on AFC. Further research is warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzofenonas / Reserva Ovárica / Infertilidad Femenina Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Fertil Steril Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzofenonas / Reserva Ovárica / Infertilidad Femenina Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Fertil Steril Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos