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Comorbidities in patients with vascular dementia and Alzheimer's disease with Neuropsychiatric symptoms.
Gainey, Mallory; Niles, Addison; Imeh-Nathaniel, Samuel; Goodwin, Richard L; Roley, Laurie Theriot; Win, Ohmar; Nathaniel, Thomas I; Imeh-Nathaniel, Adebobola.
Afiliación
  • Gainey M; University of South Carolina, School of Medicine-Greenville, 701 Grove Rd, Greenville, SC, 29605, USA.
  • Niles A; PRISMA Health UP-State South Carolina, 701 Grove Rd, Greenville, SC, 29605, USA.
  • Imeh-Nathaniel S; North Greenville University, 7801 N Tigerville Rd, Tigerville, SC, 29688, USA.
  • Goodwin RL; University of South Carolina, Columbia, SC, 29208, USA.
  • Roley LT; PRISMA Health UP-State South Carolina, 701 Grove Rd, Greenville, SC, 29605, USA.
  • Win O; PRISMA Health UP-State South Carolina, 701 Grove Rd, Greenville, SC, 29605, USA.
  • Nathaniel TI; University of South Carolina, School of Medicine-Greenville, 701 Grove Rd, Greenville, SC, 29605, USA. Electronic address: nathanit@greenvillemed.sc.edu.
  • Imeh-Nathaniel A; North Greenville University, 7801 N Tigerville Rd, Tigerville, SC, 29688, USA.
Geriatr Nurs ; 57: 217-223, 2024.
Article en En | MEDLINE | ID: mdl-38696879
ABSTRACT

INTRODUCTION:

This study aimed to examine baseline risk factors in Alzheimer's Disease (AD) and Vascular dementia (VaD) patients with neuropsychiatry symptoms (NPS), and determine whether specific risk factors differ by subtypes of dementia for AD and VaD patients with NPS.

METHODS:

A retrospective data analysis was conducted to evaluate similarities and differences in the risk factors for AD and VaD with NPS. The analysis included 2949 patients with VaD and 6341 patients with clinical confirmation of AD and VaD with or without NPS collected between February 2016 and August 2021. The multivariate logistic regression analysis was used to determine the risk factors associated with AD and VaD with NPS, by predicting the increasing odds (odds ratios (ORs) of an association of a specific baseline risk factor with AD or VaD with NPS. The validity of the regression models was tested using a Hosmer-Lemeshow test, while the Receiver Operating Curve (ROC) was used to test the sensitivity of the models.

RESULTS:

In the adjusted analysis TSH (OR = 1.781, 95 % CI, p = 0.0025) and CHF (OR = 1.620, 95 %, p = 0.016) were associated with VaD with NPS, while a history of emergency department(ED) admission (OR = 0.277, 95 % CI, p = 0.003) likely to be associated with VaD patients without NPS. For AD patients, a history of CVA (OR = 1.395, 95 % CI, p = 0.032) and cancer (OR = 1.485, 95 % CI, p = 0.013) were associated with AD patients with NPS.

DISCUSSION:

The findings of this study indicate that an abnormal thyroid gland and CHF were linked to VaD patients with behavioral disturbances, while CVA and cancer were linked to AD patients with behavioral disturbances. These findings suggest the need to develop management strategies for the care of patients with AD and VaD with NPS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia Vascular / Comorbilidad / Enfermedad de Alzheimer Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Geriatr Nurs Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia Vascular / Comorbilidad / Enfermedad de Alzheimer Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Geriatr Nurs Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos