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Rhabdomyolysis, Acute Kidney Injury, and Mortality in Ebola Virus Disease: Retrospective Analysis of Cases From the Eastern Democratic Republic of the Congo, 2019.
Kasereka, Masumbuko Claude; Mukadi-Bamuleka, Daniel; Kitenge-Omasumbu, Richard; Edidi-Atani, François; Kuamfumu, Meris Matondo; Mulangu, Sabue; Tshiani-Mbaya, Olivier; Malengera Vicky, Kambale; Mbala-Kingebeni, Placide; Ahuka-Mundeke, Steve; Muyembe-Tamfum, Jean-Jacques; Lee, Bonita E; Houston, Stan; Mumtaz, Zubia; Hawkes, Michael T.
Afiliación
  • Kasereka MC; Department of Medicine, Université Catholique du Graben, Butembo, Democratic Republic of the Congo.
  • Mukadi-Bamuleka D; School of Public Health, University of Alberta, Edmonton, Canada.
  • Kitenge-Omasumbu R; Department of Virology, Institut National de Recherche Biomédicale.
  • Edidi-Atani F; Service of Microbiology, Department of Medical Biology, University of Kinshasa.
  • Kuamfumu MM; Programme National d'Urgences et Actions Humanitaires, Ministry of Health of the Democratic Republic of the Congo, Kinshasa.
  • Mulangu S; Department of Virology, Institut National de Recherche Biomédicale.
  • Tshiani-Mbaya O; Service of Microbiology, Department of Medical Biology, University of Kinshasa.
  • Malengera Vicky K; Department of Virology, Institut National de Recherche Biomédicale.
  • Mbala-Kingebeni P; Service of Microbiology, Department of Medical Biology, University of Kinshasa.
  • Ahuka-Mundeke S; Department of Virology, Institut National de Recherche Biomédicale.
  • Muyembe-Tamfum JJ; Service of Microbiology, Department of Medical Biology, University of Kinshasa.
  • Lee BE; Department of Virology, Institut National de Recherche Biomédicale.
  • Houston S; Service of Microbiology, Department of Medical Biology, University of Kinshasa.
  • Mumtaz Z; Department of Medicine, Université Catholique du Graben, Butembo, Democratic Republic of the Congo.
  • Hawkes MT; Department of Virology, Institut National de Recherche Biomédicale.
J Infect Dis ; 230(2): e465-e473, 2024 Aug 16.
Article en En | MEDLINE | ID: mdl-38696335
ABSTRACT

BACKGROUND:

Skeletal muscle injury in Ebola virus disease (EVD) has been reported, but its association with morbidity and mortality remains poorly defined.

METHODS:

This retrospective study included patients admitted to 2 EVD treatment units over an 8-month period in 2019 during an EVD epidemic in the Democratic Republic of the Congo.

RESULTS:

An overall 333 patients (median age, 30 years; 58% female) had at least 1 creatine kinase (CK) measurement (n = 2229; median, 5/patient [IQR, 1-11]). Among patients, 271 (81%) had an elevated CK level (>380 U/L); 202 (61%) had rhabdomyolysis (CK >1000 IU/L); and 45 (14%) had severe rhabdomyolysis (≥5000 U/L). Among survivors, the maximum CK level was a median 1600 (IQR, 550-3400), peaking 3.4 days after admission (IQR, 2.3-5.5) and decreasing thereafter. Among fatal cases, the CK rose monotonically until death, with a median maximum CK level of 2900 U/L (IQR, 1500-4900). Rhabdomyolysis at admission was an independent predictor of acute kidney injury (adjusted odds ratio, 2.2 [95% CI, 1.2-3.8]; P = .0065) and mortality (adjusted hazard ratio, 1.7 [95% CI, 1.03-2.9]; P = .037).

CONCLUSIONS:

Rhabdomyolysis is associated with acute kidney injury and mortality in patients with EVD. These findings may inform clinical practice by identifying laboratory monitoring priorities and highlighting the importance of fluid management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rabdomiólisis / Fiebre Hemorrágica Ebola / Lesión Renal Aguda Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: J Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: República Democrática del Congo Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rabdomiólisis / Fiebre Hemorrágica Ebola / Lesión Renal Aguda Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: J Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: República Democrática del Congo Pais de publicación: Estados Unidos