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Pyridinium-Yne Click Polymerization: A Facile Strategy toward Functional Poly(Vinylpyridinium Salt)s with Multidrug-Resistant Bacteria Killing Ability.
He, Benzhao; Li, Ying; Li, Meng; Kang, Miaomiao; Liu, Xinyue; Huang, Jiachang; Wang, Dong; Lam, Jacky W Y; Tang, Ben Zhong.
Afiliación
  • He B; Center for Advanced Materials Research, Instrumentation and Service Center for Science and Technology, Beijing Normal University, Zhuhai, 519085, China.
  • Li Y; Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates (South China University of Technology), Guangzhou, 510640, China.
  • Li M; Innovation Research Center for AIE Pharmaceutical Biology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.
  • Kang M; Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.
  • Liu X; Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.
  • Huang J; Department of Chemistry, The Hong Kong University of Science & Technology, Kowloon, Hong Kong, China.
  • Wang D; Center for Advanced Materials Research, Instrumentation and Service Center for Science and Technology, Beijing Normal University, Zhuhai, 519085, China.
  • Lam JWY; Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.
  • Tang BZ; Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.
Angew Chem Int Ed Engl ; 63(29): e202405030, 2024 07 15.
Article en En | MEDLINE | ID: mdl-38695837
ABSTRACT
Polymeric materials with antibacterial properties hold great promise for combating multidrug-resistant bacteria, which pose a significant threat to public health. However, the synthesis of most antibacterial polymers typically involves complicated and time-consuming procedures. In this study, we demonstrate a simple and efficient strategy for synthesizing functional poly(vinylpyridinium salt)s via pyridinium-yne click polymerization. This click polymerization could proceed with high atom economy under mild conditions without any external catalyst, yielding soluble and thermally stable poly(vinylpyridinium salt)s with satisfactory molecular weights and well-defined structures in excellent yields. Additionally, the incorporation of luminescent units such as fluorene, tetraphenylethylene, and triphenylamine into the polymer backbone confers excellent aggregation-enhanced emission properties upon the resulting polymers, rendering them suitable for bacterial staining. Moreover, the existence of pyridinium salt imparts intrinsic antibacterial activity against multidrug-resistant bacteria to the polymers, enabling them to effectively inhibit wound bacterial infection and significantly expedite the healing process. This work not only provides an efficient method to prepare antibacterial polymers, but also opens up the possibility of various applications of polymers in healthcare and other antibacterial fields.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Piridinio / Pruebas de Sensibilidad Microbiana / Farmacorresistencia Bacteriana Múltiple / Química Clic / Polimerizacion / Antibacterianos Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Piridinio / Pruebas de Sensibilidad Microbiana / Farmacorresistencia Bacteriana Múltiple / Química Clic / Polimerizacion / Antibacterianos Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania