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Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients.
Wang, Justin Z; Landry, Alexander P; Raleigh, David R; Sahm, Felix; Walsh, Kyle M; Goldbrunner, Roland; Yefet, Leeor S; Tonn, Jörg C; Gui, Chloe; Ostrom, Quinn T; Barnholtz-Sloan, Jill; Perry, Arie; Ellenbogen, Yosef; Hanemann, C Oliver; Jungwirth, Gerhard; Jenkinson, Michael D; Tabatabai, Ghazaleh; Mathiesen, Tiit I; McDermott, Michael W; Tatagiba, Marcos; la Fougère, Christian; Maas, Sybren L N; Galldiks, Norbert; Albert, Nathalie L; Brastianos, Priscilla K; Ehret, Felix; Minniti, Giuseppe; Lamszus, Katrin; Ricklefs, Franz L; Schittenhelm, Jens; Drummond, Katharine J; Dunn, Ian F; Pathmanaban, Omar N; Cohen-Gadol, Aaron A; Sulman, Erik P; Tabouret, Emeline; Le Rhun, Emelie; Mawrin, Christian; Moliterno, Jennifer; Weller, Michael; Bi, Wenya Linda; Gao, Andrew; Yip, Stephen; Niyazi, Maximilian; Aldape, Kenneth; Wen, Patrick Y; Short, Susan; Preusser, Matthias; Nassiri, Farshad; Zadeh, Gelareh.
Afiliación
  • Wang JZ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Landry AP; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Raleigh DR; MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada.
  • Sahm F; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Walsh KM; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Goldbrunner R; MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada.
  • Yefet LS; Department of Radiation Oncology, Neurological Surgery, and Pathology, University of California San Francisco, San Francisco, California, USA.
  • Tonn JC; Department of Neuropathology, University Hospital Heidelberg and German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Gui C; Department of Neurosurgery, Duke University, Durham, North Carolina, USA.
  • Ostrom QT; Center of Neurosurgery, Department of General Neurosurgery, University of Cologne, Cologne, Germany.
  • Barnholtz-Sloan J; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Perry A; Department of Neurosurgery, University Hospital Munich LMU, Munich, Germany.
  • Ellenbogen Y; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Hanemann CO; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Jungwirth G; MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada.
  • Jenkinson MD; Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina, USA.
  • Tabatabai G; Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
  • Mathiesen TI; Department of Neurosurgery, Duke University, Durham, North Carolina, USA.
  • McDermott MW; Center for Biomedical Informatics & Information Technology (CBIIT), National Cancer Institute, Bethesda, Maryland, USA.
  • Tatagiba M; Trans Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, Bethesda, Maryland, USA.
  • la Fougère C; Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
  • Maas SLN; Department of Pathology, University of California San Francisco, San Francisco, California, USA.
  • Galldiks N; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Albert NL; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Brastianos PK; MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada.
  • Ehret F; Peninsula Schools of Medicine, University of Plymouth University, Plymouth, UK.
  • Minniti G; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, Heidelberg, Germany.
  • Lamszus K; Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.
  • Ricklefs FL; Institute of Translational Medicine, University of Liverpool, UK.
  • Schittenhelm J; Department of Neurology and Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Tübingen, Germany.
  • Drummond KJ; Cluster of Excellence (EXC 2180) "Image Guided and Functionally Instructed Tumor Therapies," Eberhard Karls University Tübingen, Tübingen, Germany.
  • Dunn IF; Center for Neuro-Oncology, Comprehensive Cancer Center Tübingen-Stuttgart, University Hospital Tübingen, Tübingen, Germany.
  • Pathmanaban ON; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
  • Cohen-Gadol AA; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Sulman EP; Division of Neuroscience, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
  • Tabouret E; Miami Neuroscience Institute, Baptist Health of South Florida, Miami, Florida, USA.
  • Le Rhun E; Department of Neurosurgery, University of Tübingen, Tübingen, Germany.
  • Mawrin C; Center for Neuro-Oncology, Comprehensive Cancer Center Tübingen-Stuttgart, University Hospital Tübingen, Tübingen, Germany.
  • Moliterno J; Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tübingen, Germany.
  • Weller M; Cluster of Excellence (EXC 2180) "Image Guided and Functionally Instructed Tumor Therapies," Eberhard Karls University Tübingen, Tübingen, Germany.
  • Bi WL; Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Gao A; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
  • Yip S; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Niyazi M; Institute of Neuroscience and Medicine (IMN-3), Research Center Juelich, Juelich, Germany.
  • Aldape K; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
  • Wen PY; Department of Radiation Oncology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
  • Short S; Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Preusser M; Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Rome, Italy.
  • Nassiri F; Laboratory for Brain Tumor Biology, University Hospital Eppendorf, Hamburg, Germany.
  • Zadeh G; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Neuro Oncol ; 26(10): 1742-1780, 2024 Oct 03.
Article en En | MEDLINE | ID: mdl-38695575
ABSTRACT
Meningiomas are the most common primary intracranial tumors in adults and are increasing in incidence due to the aging population and increased access to neuroimaging. While most exhibit nonmalignant behavior, a subset of meningiomas are biologically aggressive and are associated with treatment resistance, resulting in significant neurologic morbidity and even mortality. In recent years, meaningful advances in our understanding of the biology of these tumors have led to the incorporation of molecular biomarkers into their grading and prognostication. However, unlike other central nervous system (CNS) tumors, a unified molecular taxonomy for meningiomas has not yet been established and remains an overarching goal of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-Not Official World Health Organization (cIMPACT-NOW) working group. Additionally, clinical equipoise still remains on how specific meningioma cases and patient populations should be optimally managed. To address these existing gaps, members of the International Consortium on Meningiomas including field-leading experts, have prepared this comprehensive consensus narrative review directed toward clinicians, researchers, and patients. Included in this manuscript are detailed overviews of proposed molecular classifications, novel biomarkers, contemporary treatment strategies, trials on systemic therapies, health-related quality-of-life studies, and management strategies for unique meningioma patient populations. In each section, we discuss the current state of knowledge as well as ongoing clinical and research challenges to road map future directions for further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Meníngeas / Meningioma Límite: Humans Idioma: En Revista: Neuro Oncol Asunto de la revista: NEOPLASIAS / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Meníngeas / Meningioma Límite: Humans Idioma: En Revista: Neuro Oncol Asunto de la revista: NEOPLASIAS / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido