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Implementation of a primary-tertiary shared care model to improve the detection of familial hypercholesterolaemia (FH): a mixed methods pre-post implementation study protocol.
Birkenhead, Karen; Sullivan, David; Trumble, Claire; Spinks, Catherine; Srinivasan, Shubha; Partington, Andrew; Elias, Luke; Hespe, Charlotte Mary; Fleming, Gabrielle; Li, Stephen; Calder, Madeline; Robertson, Elizabeth; Trent, Ronald; Sarkies, Mitchell N.
Afiliación
  • Birkenhead K; School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia karen.birkenhead@sydney.edu.au.
  • Sullivan D; Sydney Health Partners, Implementation Science Academy, Sydney, New South Wales, Australia.
  • Trumble C; Department of Chemical Pathology, NSW Health Pathology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
  • Spinks C; Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Srinivasan S; Institute of Precision Medicine and Bioinformatics, Sydney Local Health District, Sydney, New South Wales, Australia.
  • Partington A; Institute of Precision Medicine and Bioinformatics, Sydney Local Health District, Sydney, New South Wales, Australia.
  • Elias L; Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
  • Hespe CM; Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Fleming G; Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.
  • Li S; FH Australasia Support Group, Sydney, New South Wales, Australia.
  • Calder M; School of Medicine, The University of Notre Dame Australia, Sydney, New South Wales, Australia.
  • Robertson E; Institute of Precision Medicine and Bioinformatics, Sydney Local Health District, Sydney, New South Wales, Australia.
  • Trent R; Core Pathology and Clinical Chemistry, NSW Health Pathology, Westmead Hospital, Sydney, New South Wales, Australia.
  • Sarkies MN; Institute of Precision Medicine and Bioinformatics, Sydney Local Health District, Sydney, New South Wales, Australia.
BMJ Open ; 14(5): e082699, 2024 May 01.
Article en En | MEDLINE | ID: mdl-38692720
ABSTRACT

INTRODUCTION:

Familial hypercholesterolaemia (FH) is an autosomal dominant inherited disorder of lipid metabolism and a preventable cause of premature cardiovascular disease. Current detection rates for this highly treatable condition are low. Early detection and management of FH can significantly reduce cardiac morbidity and mortality. This study aims to implement a primary-tertiary shared care model to improve detection rates for FH. The primary objective is to evaluate the implementation of a shared care model and support package for genetic testing of FH. This protocol describes the design and methods used to evaluate the implementation of the shared care model and support package to improve the detection of FH. METHODS AND

ANALYSIS:

This mixed methods pre-post implementation study design will be used to evaluate increased detection rates for FH in the tertiary and primary care setting. The primary-tertiary shared care model will be implemented at NSW Health Pathology and Sydney Local Health District in NSW, Australia, over a 12-month period. Implementation of the shared care model will be evaluated using a modification of the implementation outcome taxonomy and will focus on the acceptability, evidence of delivery, appropriateness, feasibility, fidelity, implementation cost and timely initiation of the intervention. Quantitative pre-post and qualitative semistructured interview data will be collected. It is anticipated that data relating to at least 62 index patients will be collected over this period and a similar number obtained for the historical group for the quantitative data. We anticipate conducting approximately 20 interviews for the qualitative data. ETHICS AND DISSEMINATION Ethical approval has been granted by the ethics review committee (Royal Prince Alfred Hospital Zone) of the Sydney Local Health District (Protocol ID X23-0239). Findings will be disseminated through peer-reviewed publications, conference presentations and an end-of-study research report to stakeholders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atención Primaria de Salud / Hiperlipoproteinemia Tipo II Límite: Humans País/Región como asunto: Oceania Idioma: En Revista: BMJ Open Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atención Primaria de Salud / Hiperlipoproteinemia Tipo II Límite: Humans País/Región como asunto: Oceania Idioma: En Revista: BMJ Open Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido