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Oncological feasibility of segmentectomy for inner-located lung cancer.
Yano, Kaito; Yotsukura, Masaya; Watanabe, Hirokazu; Akamine, Takaki; Yoshida, Yukihiro; Nakagawa, Kazuo; Yatabe, Yasushi; Kusumoto, Masahiko; Watanabe, Shun-Ichi.
Afiliación
  • Yano K; Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • Yotsukura M; Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • Watanabe H; Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
  • Akamine T; Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • Yoshida Y; Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • Nakagawa K; Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • Yatabe Y; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.
  • Kusumoto M; Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
  • Watanabe SI; Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
JTCVS Open ; 18: 261-275, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38690420
ABSTRACT

Objective:

Oncological feasibility of segmentectomy for internal non-small cell lung cancer (NSCLC) has not been assessed adequately. We assessed the oncological feasibility of segmentectomy for inner-located NSCLC by investigating surgical margins and patient prognosis after undergoing the procedure.

Methods:

Of the 3555 patients who underwent resection for lung cancer between 2013 and 2019 at our institution, 659 patients who underwent segmentectomy for clinical stage 0 to stage1A NSCLC were included in this study. Patients were separated into 2 groups according to whether the tumor was in the inner or outer third of the lung area. Clinical characteristics and prognoses were retrospectively compared between the groups.

Results:

Of the included 659 cases, 183 (27.8%) were inner-located, and 476 (72.2%) had outer-located NSCLC. The surgical margin was significantly shorter in the inner-located group than in the outer group (median, 16 vs 25 mm; P < .001). The 5-year recurrence-free survival and overall survival probabilities were 91.1%/91.8% (P = .530) and 94.1%/95.6% (P = .345) for inner/outer-located groups, respectively. Multivariate analysis showed that clinical stage IA2 or 3 (P = .043), lymphovascular invasion (P < .001), and surgical margins <20 mm (P = .017) were independent prognostic factors for recurrence-free survival. The location of the inner or outer tumors was not related to the prognosis.

Conclusions:

For clinical stage 0 to stage1A NSCLC, tumor location in the inner two-thirds of the lung was not associated with prognosis after segmentectomy. Because one of the independent prognostic factors is margin distance, segmentectomy for inner-located NSCLC would be oncologically acceptable when an adequate surgical margin is secured.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JTCVS Open Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JTCVS Open Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos