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Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies.
Haque, Mst Farjanamul; El-Nashar, Heba A S; Akbor, Md Showkoth; Alfaifi, Mohammed; Bappi, Mehedi Hasan; Chowdhury, Afsana Kabir; Hossain, Muhammad Kamal; El-Shazly, Mohamed; Albayouk, Tala; Saleh, Na'il; Islam, Muhammad Torequl.
Afiliación
  • Haque MF; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
  • El-Nashar HAS; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
  • Akbor MS; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
  • Alfaifi M; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
  • Bappi MH; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
  • Chowdhury AK; Department of Pharmacy, East West University, Dhaka, Bangladesh.
  • Hossain MK; School of Pharmacy, Jeonbuk National University, Jeonju, Republic of Korea.
  • El-Shazly M; Department of Pharmacy, University of Science and Technology Chittagiong, Chittagong, Bangladesh.
  • Albayouk T; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
  • Saleh N; Department of Chemistry, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates.
  • Islam MT; Department of Chemistry, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates.
Front Chem ; 12: 1366844, 2024.
Article en En | MEDLINE | ID: mdl-38690012
ABSTRACT

Introduction:

D-pinitol, a naturally occurring inositol, has diverse biological activities like antioxidant, antimicrobial and anticancer activities. This study aimed to evaluate anti-inflammatory effect of d-pinitol in a chick model. Additionally, in silico studies were performed to evaluate the molecular interactions with cyclooxygenase-2 (COX-2).

Methods:

The tested groups received d-pinitol (12.5, 25, and 50 mg/kg) and the standard drugs celecoxib and ketoprofen (42 mg/kg) via oral gavage prior to formalin injection. Then, the number of licks was counted for the first 10 min, and the paw edema diameter was measured at 60, 90, and 120 min. Results and

Discussion:

The d-pinitol groups significantly (p < 0.05) reduced the number of paw licks and paw edema diameters, compared to negative control. When d-pinitol was combined with celecoxib, it reduced inflammatory parameters more effectively than the individual groups. The in silico study showed a promising binding capacity of d-pinitol with COX-2. Taken together, d-pinitol exerted anti-inflammatory effects in a dose-dependent manner, possibly through COX-2 interaction pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Chem Año: 2024 Tipo del documento: Article País de afiliación: Bangladesh Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Chem Año: 2024 Tipo del documento: Article País de afiliación: Bangladesh Pais de publicación: Suiza