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The 5-HT7 receptor antagonist SB 269970 ameliorates maternal fluoxetine exposure-induced impairment of synaptic plasticity in the prefrontal cortex of the offspring female mice.
Bobula, Bartosz; Kusek, Magdalena; Hess, Grzegorz.
Afiliación
  • Bobula B; Department of Physiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland. Electronic address: bobula@if-pan.krakow.pl.
  • Kusek M; Department of Physiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland. Electronic address: kusek@if-pan.krakow.pl.
  • Hess G; Department of Physiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland. Electronic address: grzegorz.hess@uj.edu.pl.
Pharmacol Biochem Behav ; 240: 173779, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38688436
ABSTRACT
The use of a selective serotonin reuptake inhibitor fluoxetine in depression during pregnancy and the postpartum period might increase the risk of affective disorders and cognitive symptoms in progeny. In animal models, maternal exposure to fluoxetine throughout gestation and lactation negatively affects the behavior of the offspring. Little is known about the effects of maternal fluoxetine on synaptic transmission and plasticity in the offspring cerebral cortex. During pregnancy and lactation C57BL/6J mouse dams received fluoxetine (7.5 mg/kg/day) with drinking water. Female offspring mice received intraperitoneal injections of the selective 5-HT7 receptor antagonist SB 269970 (2.5 mg/kg) for 7 days. Whole-cell and field potential electrophysiological recordings were performed in the medial prefrontal cortex (mPFC) ex vivo brain slices. Perinatal exposure to fluoxetine resulted in decreased field potentials and impaired long-term potentiation (LTP) in layer II/III of the mPFC of female young adult offspring. Neither the intrinsic excitability nor spontaneous excitatory postsynaptic currents were altered in layer II/III mPFC pyramidal neurons. In mPFC slices obtained from fluoxetine-treated mice that were administered SB 269970 both field potentials and LTP magnitude were restored and did not differ from controls. Treatment of fluoxetine-exposed mice with a selective 5-HT7 receptor antagonist, SB 269970, normalizes synaptic transmission and restores the potential for plasticity in the mPFC of mice exposed in utero and postnatally to fluoxetine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Efectos Tardíos de la Exposición Prenatal / Sulfonamidas / Fluoxetina / Receptores de Serotonina / Corteza Prefrontal / Ratones Endogámicos C57BL / Plasticidad Neuronal Límite: Animals / Pregnancy Idioma: En Revista: Pharmacol Biochem Behav Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Efectos Tardíos de la Exposición Prenatal / Sulfonamidas / Fluoxetina / Receptores de Serotonina / Corteza Prefrontal / Ratones Endogámicos C57BL / Plasticidad Neuronal Límite: Animals / Pregnancy Idioma: En Revista: Pharmacol Biochem Behav Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos