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Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer.
Wang, Juan; Li, Boxuan; Cooper, Remy C; Huang, Da; Yang, Hu.
Afiliación
  • Wang J; College of Biomedical Engineering, Sichuan University, Chengdu 610065, Sichuan, China.
  • Li B; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences &
  • Cooper RC; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, United States.
  • Huang D; College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian, China.
  • Yang H; Linda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409, United States.
Biomacromolecules ; 25(5): 2770-2779, 2024 05 13.
Article en En | MEDLINE | ID: mdl-38687975
ABSTRACT
Drug repurposing uses approved drugs as candidate anticancer therapeutics, harnesses previous research and development efforts, and benefits from available clinically suitable formulations and evidence of patient tolerability. In this work, the drug used clinically to treat chronic alcoholism, disulfiram (DSF), was studied for its antitumor efficacy in a copper-dependent manner. The combination of DSF and copper could achieve a tumor cell growth inhibition effect comparable to those of 5-fluorouracil and taxol on head and neck cancer cells. Both bulk dendrimer hydrogel and microsized dendrimer hydrogel particles were utilized for the localized sustained release of copper in the tumor site. The localized sustained release of copper facilitated the tumor inhibition effect following intratumoral injection in a mouse's head and neck cancer model.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cobre / Preparaciones de Acción Retardada / Disulfiram / Neoplasias de Cabeza y Cuello Límite: Animals / Humans Idioma: En Revista: Biomacromolecules Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cobre / Preparaciones de Acción Retardada / Disulfiram / Neoplasias de Cabeza y Cuello Límite: Animals / Humans Idioma: En Revista: Biomacromolecules Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos