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The Effects of Computerized Cognitive Training in Older Adults' Cognitive Performance and Biomarkers of Structural Brain Aging.
Lee, Hyun Kyu; Basak, Chandramallika; Grant, Sarah-Jane; Ray, Nicholas R; Skolasinska, Paulina A; Oehler, Chris; Qin, Shuo; Sun, Andrew; Smith, Evan T; Sherard, G Hulon; Rivera-Dompenciel, Adriana; Merzenich, Mike; Voss, Michelle W.
Afiliación
  • Lee HK; Department of Research and Development, Posit Science Corporation, San Francisco, California, USA.
  • Basak C; Department of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
  • Grant SJ; Department of Research and Development, Posit Science Corporation, San Francisco, California, USA.
  • Ray NR; Department of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
  • Skolasinska PA; Department of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
  • Oehler C; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA.
  • Qin S; Department of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
  • Sun A; Department of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
  • Smith ET; Department of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
  • Sherard GH; Department of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
  • Rivera-Dompenciel A; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA.
  • Merzenich M; Department of Research and Development, Posit Science Corporation, San Francisco, California, USA.
  • Voss MW; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA.
J Gerontol B Psychol Sci Soc Sci ; 79(7)2024 Jul 01.
Article en En | MEDLINE | ID: mdl-38686621
ABSTRACT

OBJECTIVES:

Cognitive training (CT) has been investigated as a means of delaying age-related cognitive decline in older adults. However, its impact on biomarkers of age-related structural brain atrophy has rarely been investigated, leading to a gap in our understanding of the linkage between improvements in cognition and brain plasticity. This study aimed to explore the impact of CT on cognitive performance and brain structure in older adults.

METHODS:

One hundred twenty-four cognitively normal older adults recruited from 2 study sites were randomly assigned to either an adaptive CT (n = 60) or a casual game training (active control, AC, n = 64).

RESULTS:

After 10 weeks of training, CT participants showed greater improvements in the overall cognitive composite score (Cohen's d = 0.66, p < .01) with nonsignificant benefits after 6 months from the completion of training (Cohen's d = 0.36, p = .094). The CT group showed significant maintenance of the caudate volume as well as significant maintained fractional anisotropy in the left internal capsule and in left superior longitudinal fasciculus compared to the AC group. The AC group displayed an age-related decrease in these metrics of brain structure.

DISCUSSION:

Results from this multisite clinical trial demonstrate that the CT intervention improves cognitive performance and helps maintain caudate volume and integrity of white matter regions that are associated with cognitive control, adding to our understanding of the changes in brain structure contributing to changes in cognitive performance from adaptive CT. CLINICAL TRIAL REGISTRATION NCT03197454.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo Límite: Aged / Female / Humans / Male Idioma: En Revista: J Gerontol B Psychol Sci Soc Sci Asunto de la revista: CIENCIAS SOCIAIS / GERIATRIA / PSICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo Límite: Aged / Female / Humans / Male Idioma: En Revista: J Gerontol B Psychol Sci Soc Sci Asunto de la revista: CIENCIAS SOCIAIS / GERIATRIA / PSICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos