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Glycemic variability is associated with sural nerve conduction velocity in outpatients with type 2 diabetes: Usefulness of a new point-of-care device for nerve conduction studies.
Morita, Machiko; Sada, Kentaro; Hidaka, Shuji; Ogawa, Miki; Shibata, Hirotaka.
Afiliación
  • Morita M; Department of Diabetes and Metabolism, Koseiren Tsurumi Hospital, Oita, Japan.
  • Sada K; Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Oita, Japan.
  • Hidaka S; Department of Diabetes and Metabolism, Koseiren Tsurumi Hospital, Oita, Japan.
  • Ogawa M; Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Oita, Japan.
  • Shibata H; Department of Diabetes and Metabolism, Koseiren Tsurumi Hospital, Oita, Japan.
J Diabetes Investig ; 15(8): 1075-1083, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38685597
ABSTRACT
AIMS/

INTRODUCTION:

Although several studies have shown the association between continuous glucose monitoring (CGM)-derived glycemic variability (GV) and diabetic peripheral neuropathy, no studies have focused on outpatients or used NC-stat®/DPNCheck™, a new point-of-care device for nerve conduction study (NCS). We investigated the association between CGM-derived GV and NCS using DPNCheck™ in outpatients with type 2 diabetes, and further analyzed the difference in results between patients with and without well-controlled HbA1c levels. MATERIALS AND

METHODS:

All outpatients with type 2 diabetes using the CGM device (FreeStyle Libre Pro®) between 2017 and 2022 were investigated. Sural nerve conduction was evaluated by sensory nerve action potential (SNAP) amplitude and sensory conduction velocity (SCV) using DPNCheck™. Associations of CGM-derived GV metrics with SNAP amplitude and SCV were investigated.

RESULTS:

In total, 304 outpatients with type 2 diabetes were included. In a linear regression model, most CGM-derived GV metrics except for the mean amplitude of glucose excursion and low blood glucose index were significantly associated with SCV, but not with SNAP amplitude. The significant associations of most CGM-derived GV metrics with SCV remained after adjustment for possible confounding factors, but not after adjustment for glycated hemoglobin (HbA1c). Most CGM-derived GV metrics were significantly associated with SCV after adjustment for HbA1c in patients with a HbA1c ≤ 6.9%, but not in those with a HbA1c ≥ 7.0%.

CONCLUSIONS:

In outpatients with type 2 diabetes, multiple CGM-derived GV metrics were significantly associated with SCV obtained by DPNCheck™. GV may have independent impacts on peripheral nerve function, particularly in patients with well-controlled HbA1c levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pacientes Ambulatorios / Nervio Sural / Sistemas de Atención de Punto / Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas / Estudios de Conducción Nerviosa / Conducción Nerviosa Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Diabetes Investig Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pacientes Ambulatorios / Nervio Sural / Sistemas de Atención de Punto / Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas / Estudios de Conducción Nerviosa / Conducción Nerviosa Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Diabetes Investig Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón