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Pulmonary diseases in patients with classical Hodgkin lymphoma relative to a matched background population: A Danish national cohort study.
Vandtved, Julie Haugaard; Øvlisen, Andreas Kiesbye; Baech, Joachim; Weinrich, Ulla Møller; Severinsen, Marianne Tang; Maksten, Eva Futtrup; Jakobsen, Lasse Hjort; Glimelius, Ingrid; Kamper, Peter; Hutchings, Martin; Specht, Lena; Dahl-Sørensen, Rasmus; Christensen, Jacob Haaber; El-Galaly, Tarec C.
Afiliación
  • Vandtved JH; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Øvlisen AK; Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
  • Baech J; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Weinrich UM; Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
  • Severinsen MT; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Maksten EF; Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
  • Jakobsen LH; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Glimelius I; Department of Respiratory Diseases, Aalborg University Hospital, Aalborg, Denmark.
  • Kamper P; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Hutchings M; Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
  • Specht L; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Dahl-Sørensen R; Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
  • Christensen JH; Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
  • El-Galaly TC; Department of Immunology, Genetics and Pathology, Uppsala University Hospital, Uppsala, Sweden.
Br J Haematol ; 205(2): 542-551, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38685596
ABSTRACT
Late toxicities can impact survivorship in patients with classical Hodgkin lymphoma (cHL) with pulmonary toxicity after bleomycin-containing chemotherapy being a concern. The incidence of pulmonary diseases was examined in this Danish population-based study. A total of 1474 adult patients with cHL treated with ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) or BEACOPP (bleomycin, vincristine, etoposide, doxorubicin, cyclophosphamide, procarbazine and prednisone) between 2000 and 2018 were included along with 7370 age- and sex-matched comparators from the background population. Median follow-up was 8.6 years for the patients. Patients with cHL had increased risk of incident pulmonary diseases (HR 2.91 [95% CI 2.30-3.68]), with a 10-year cumulative risk of 7.4% versus 2.9% for comparators. Excess risks were observed for interstitial lung diseases (HR 15.84 [95% CI 9.35-26.84]) and chronic obstructive pulmonary disease (HR 1.99 [95% CI 1.43-2.76]), with a 10-year cumulative risk of 4.1% and 3.5% respectively for patients. No excess risk was observed for asthma (HR 0.82 [95% CI 0.43-1.56]). Risk factors for interstitial lung diseases were age ≥60 years, the presence of B-symptoms and low albumin. These findings document a significant burden of pulmonary diseases among patients with cHL and emphasize the importance of diagnostic work-up of pulmonary symptoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Protocolos de Quimioterapia Combinada Antineoplásica / Enfermedades Pulmonares País/Región como asunto: Europa Idioma: En Revista: Br J Haematol Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Protocolos de Quimioterapia Combinada Antineoplásica / Enfermedades Pulmonares País/Región como asunto: Europa Idioma: En Revista: Br J Haematol Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido