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Resolution of Food Protein-Induced Enterocolitis Syndrome-A Long-Term Follow-Up Study of 113 Swedish Children.
Ullberg, Josefin; Ullberg, Disa; Fech-Bormann, Mareike; Fagerberg, Ulrika L.
Afiliación
  • Ullberg J; Department of Pediatrics, Västmanland Hospital Västerås, Västerås, Sweden. Electronic address: josefin.ullberg@regionvastmanland.se.
  • Ullberg D; Linköping University, Linköping, Sweden.
  • Fech-Bormann M; Department of Pediatrics, Västmanland Hospital Västerås, Västerås, Sweden.
  • Fagerberg UL; Department of Pediatrics, Västmanland Hospital Västerås, Västerås, Sweden; Center for Clinical Research, Västmanland Hospital Västerås, Region Västmanland-Uppsala University, Västerås, Sweden; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
J Allergy Clin Immunol Pract ; 12(8): 2127-2134.e1, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38685480
ABSTRACT

BACKGROUND:

Food protein-induced enterocolitis syndrome (FPIES), a non-IgE-mediated allergy, primarily affects infants and young children. Whether and when tolerance develops seems to vary among populations and trigger foods.

OBJECTIVE:

This study aimed to evaluate tolerance development and its assessment in a Swedish cohort.

METHODS:

This was a prospective follow-up study of a Swedish cohort of 113 children, followed at 25 pediatric departments, with acute FPIES. Data on oral food challenges and FPIES resolution were collected through chart reviews and, if incomplete, supplemental caregiver interviews.

RESULTS:

The median age at last follow-up was 5.6 years (range 8.7 months to 16.5 years). Eighty-three children (73%) developed tolerance to 96 of 137 (70%) foods 93% for cow's milk, 92% for oat, and 46% for fish. The median age when tolerance was developed was 36.0 months (interquartile range 23.7-48.2 months) 24.4 months for cow's milk, 30.1 months for oat, and 49.4 months for fish. Tolerance was determined in hospital in 45% of cases. Five percent demonstrated allergic sensitization to their FPIES trigger food. Age at tolerance development did not differ between sensitized and nonsensitized patients.

CONCLUSIONS:

Most of the children in this Swedish cohort with FPIES achieved tolerance before age 4 years. Cow's milk- and oat-induced FPIES had similar remission patterns, with early resolution. Development of tolerance to fish occurred significantly later compared with all other FPIES-inducing foods.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterocolitis / Hipersensibilidad a los Alimentos Límite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: J Allergy Clin Immunol Pract Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterocolitis / Hipersensibilidad a los Alimentos Límite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: J Allergy Clin Immunol Pract Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos