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L-DOPA regulates neuroinflammation and Aß pathology through NEP and ADAM17 in a mouse model of AD.
Lee, Hyun-Ju; Nam, JinHan; Hwang, Jeong-Woo; Park, Jin-Hee; Jeong, Yoo Joo; Jang, Ji-Yeong; Kim, Su-Jeong; Jo, A-Ran; Hoe, Hyang-Sook.
Afiliación
  • Lee HJ; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Dong-Gu, Daegu, 41068, Korea.
  • Nam J; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Dong-Gu, Daegu, 41068, Korea.
  • Hwang JW; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Dong-Gu, Daegu, 41068, Korea.
  • Park JH; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Dong-Gu, Daegu, 41068, Korea.
  • Jeong YJ; Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, 42988, Korea.
  • Jang JY; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Dong-Gu, Daegu, 41068, Korea.
  • Kim SJ; Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, 42988, Korea.
  • Jo AR; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-Ro, Dong-Gu, Daegu, 41068, Korea.
  • Hoe HS; Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, 42988, Korea.
Mol Brain ; 17(1): 21, 2024 Apr 30.
Article en En | MEDLINE | ID: mdl-38685105
ABSTRACT
Dopamine plays important roles in cognitive function and inflammation and therefore is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Drugs that increase or maintain dopamine levels in the brain could be a therapeutic strategy for AD. However, the effects of dopamine and its precursor levodopa (L-DOPA) on Aß/tau pathology in vivo and the underlying molecular mechanisms have not been studied in detail. Here, we investigated whether L-DOPA treatment alters neuroinflammation, Aß pathology, and tau phosphorylation in 5xFAD mice, a model of AD. We found that L-DOPA administration significantly reduced microgliosis and astrogliosis in 5xFAD mice. In addition, L-DOPA treatment significantly decreased Aß plaque number by upregulating NEP and ADAM17 levels in 5xFAD mice. However, L-DOPA-treated 5xFAD mice did not exhibit changes in tau hyperphosphorylation or tau kinase levels. These data suggest that L-DOPA alleviates neuroinflammatory responses and Aß pathology but not tau pathology in this mouse model of AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratones Transgénicos / Levodopa / Péptidos beta-Amiloides / Proteínas tau / Modelos Animales de Enfermedad / Enfermedad de Alzheimer / Proteína ADAM17 / Enfermedades Neuroinflamatorias Límite: Animals Idioma: En Revista: Mol Brain Asunto de la revista: BIOLOGIA MOLECULAR / CEREBRO Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratones Transgénicos / Levodopa / Péptidos beta-Amiloides / Proteínas tau / Modelos Animales de Enfermedad / Enfermedad de Alzheimer / Proteína ADAM17 / Enfermedades Neuroinflamatorias Límite: Animals Idioma: En Revista: Mol Brain Asunto de la revista: BIOLOGIA MOLECULAR / CEREBRO Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido