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The Relationship of Microsatellite Instability with BRAF and p53 Mutations and Histopathological Parameters in Colorectal Adenocarcinoma.
Gündogar, Özgecan; Bektas, Sibel; Yildirim, Emine; Gönüllü, Dogan.
Afiliación
  • Gündogar Ö; Department of Pathology, University of Health Sciences Turkey, Gaziosmanpasa Training and Research Hospital, 34255 Gaziosmanpasa, Istanbul, Turkey.
  • Bektas S; Department of Pathology, University of Health Sciences Turkey, Gaziosmanpasa Training and Research Hospital, 34255 Gaziosmanpasa, Istanbul, Turkey.
  • Yildirim E; Department of General Surgery, University of Health Sciences Turkey, Gaziosmanpasa Training and Research Hospital, 34255 Gaziosmanpasa, Istanbul, Turkey.
  • Gönüllü D; Department of General Surgery, University of Health Sciences Turkey, Gaziosmanpasa Training and Research Hospital, 34255 Gaziosmanpasa, Istanbul, Turkey.
Ann Ital Chir ; 95(2): 181-191, 2024.
Article en En | MEDLINE | ID: mdl-38684491
ABSTRACT

AIM:

This study aims to elucidate the associations between microsatellite instability (MSI) status, BRAF mutation, and p53 reactions with pathological parameters and survival outcomes in colorectal carcinoma. MATERIAL AND

METHOD:

MutL homologous 1 (MLH1), Postmeiotic segregation increased 2 (PMS2), MutS homologous 2 (MSH2), MutS homologous 6 (MSH6), BRAF, and p53 antibodies were performed on 130 adenocarcinoma samples, including 65 from the right colon and 65 from the left colon. The relationships of MSI status with BRAF mutation, p53 reaction, clinical and pathological parameters, and survival times were statistically analyzed.

RESULTS:

A statistically significant relationship was found between MSI and right colon localization, tumor size, histological grade, intraepithelial tumor-infiltrating lymphocytes, Crohn-like lymphocytic reaction, expansive growth pattern, and BRAF mutation (p < 0.05). No significant correlation was found between MSI status and the disease-free or overall survival times (p > 0.05).

CONCLUSION:

In colorectal adenocarcinoma, MSI and BRAF mutation are associated with parameters, indicating the host immune response and prognostic histopathological parameters, including tumor size and histological grade. The evaluation of MSI status and BRAF mutation can be particularly informative for predicting the prognosis and guiding the treatment management in poorly differentiated colorectal adenocarcinoma. Understanding the mechanisms of molecular carcinogenesis in colorectal carcinoma and organizing treatment algorithms based on molecular foundations will increase the success of the treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenocarcinoma / Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas B-raf / Inestabilidad de Microsatélites / Mutación Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Ital Chir Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenocarcinoma / Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas B-raf / Inestabilidad de Microsatélites / Mutación Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Ital Chir Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Italia