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Hepatic insufficiency in two juvenile dogs with histoplasmosis.
Whitman, Rachel E; Cagle, Laura A; Bosch, Sarah; Alas, Oscar B; Vilaplana Grosso, Federico R; Lanier, Christopher J; Heinrich, Daniel A; Sharkey, Leslie C.
Afiliación
  • Whitman RE; Department of Comparative, Diagnostic, and Population Medicine, University of Florida, Gainesville, Florida, USA.
  • Cagle LA; Department of Comparative, Diagnostic, and Population Medicine, University of Florida, Gainesville, Florida, USA.
  • Bosch S; Department of Comparative, Diagnostic, and Population Medicine, University of Florida, Gainesville, Florida, USA.
  • Alas OB; Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
  • Vilaplana Grosso FR; Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
  • Lanier CJ; Department of Comparative, Diagnostic, and Population Medicine, University of Florida, Gainesville, Florida, USA.
  • Heinrich DA; Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, Minnesota, USA.
  • Sharkey LC; Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.
Vet Clin Pathol ; 53(2): 242-249, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38684471
ABSTRACT
A 9-month-old female intact toy poodle and a 1-year-old female intact Labrador retriever mix presented to separate teaching hospitals for chronic histories of malaise and clinicopathologic evidence of hepatic dysfunction. The signalment and clinical histories of these dogs prompted consideration of a congenital portosystemic shunt as a primary differential. However, microscopic evaluation of peritoneal effusion, pleural effusion, and peripheral blood samples from the dogs revealed round to ovoid yeast organisms morphologically most compatible with Histoplasma capsulatum. Additional testing confirmed histoplasmosis in each case. The poodle underwent a computed tomography (CT) study, which showed hepatomegaly with a spleno-gonadal shunt, pancreatic and gastric wall edema, and marked peritoneal effusion, findings compatible with portal hypertension and secondary acquired shunt formation. The dog was later humanely euthanized due to clinical deterioration, and on necropsy hepatic histoplasmosis was verified, with additional affected tissues comprising lungs and spleen. The Labrador Retriever mix responded clinically and clinicopathologically to antifungal therapy, though no abdominal imaging was performed to definitively exclude the possibility of a congenital portosystemic shunt. In retrospect, several features were more compatible with histoplasmosis than portosystemic shunt in these cases, including hyperbilirubinemia, effusion, and hepatomegaly. These findings serve as a reminder of the need to interpret serum biochemical findings in the context of the totality of the clinicopathologic data and imaging findings, as well as the diagnostic value of microscopy in the evaluation of hematologic and body cavity fluid samples.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Perros / Histoplasmosis Límite: Animals Idioma: En Revista: Vet Clin Pathol Asunto de la revista: MEDICINA VETERINARIA / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Perros / Histoplasmosis Límite: Animals Idioma: En Revista: Vet Clin Pathol Asunto de la revista: MEDICINA VETERINARIA / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos