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Secondary metabolites from the stem bark of Alstonia boonei and the seeds of Picralima nitida with antibacterial activities.
Adepiti, Awodayo Oluwatoyin; Nyamboki, Divinah Kwamboka; Kibrom, Gebreheiwot Bedane; Elujoba, Anthony Adebolu; Spiteller, Michael; Matasyoh, Josphat Clement.
Afiliación
  • Adepiti AO; Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Dortmund, Germany.
  • Nyamboki DK; Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
  • Kibrom GB; Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Dortmund, Germany.
  • Elujoba AA; Department of Chemistry, Faculty of Sciences, Egerton University, Egerton, Kenya.
  • Spiteller M; Department of Chemistry, Addis Ababa University, Addis Ababa, Ethiopia.
  • Matasyoh JC; Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
Nat Prod Res ; : 1-6, 2024 Apr 29.
Article en En | MEDLINE | ID: mdl-38684042
ABSTRACT
The methanol stem bark extract of A. boonei and methanol seed extract of P. nitida, were subjected to purification using chromatographic techniques. A. boonei yielded loganic acid (1), sweroside (2) and secoxyloganin (3), while P. nitida afforded (1), akuammidine (4), akuammicine (5) and alstonine (6). The structures of the compounds were elucidated based on their nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HRMS) profiles and comparison with literature data. The antibacterial activities of the compounds were evaluated using the disc diffusion assay with chloramphenicol as the positive control. Alstonine (6) demonstrated weak activity against Pseudomonas aeruginosa and Streptococcus agalactiae with zones of inhibition of 9.3 ± 0.6 and 10.0 ± 0.0 mm, respectively. This is the first report of sweroside (2) and secoxyloganin (3) in A. boonei.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido