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Perinatal outcomes following early prenatal diagnosis: insights from a single-center experience with Ebstein anomaly and tricuspid valve dysplasia.
Dedeoglu, Reyhan; Akbulut, Damla Gokcer; Turkmen, Emine; Dedeoglu, Savas; Bornaun, Helen.
Afiliación
  • Dedeoglu R; Department of Pediatric Cardiology, Istanbul University-Cerrahpasa Cerrahpasa Medical School, Istanbul, Turkey. reyhandedeoglu@gmail.com.
  • Akbulut DG; Department of Pediatric Cardiology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.
  • Turkmen E; Department of Obstetrics and Gynecology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.
  • Dedeoglu S; Department of Pediatrics, Uskudar University Medical Faculty, Istanbul, Turkey.
  • Bornaun H; Department of Pediatric Cardiology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.
Arch Gynecol Obstet ; 310(3): 1491-1497, 2024 09.
Article en En | MEDLINE | ID: mdl-38683395
ABSTRACT

PURPOSE:

Ebstein anomaly (EA) and tricuspid valve dysplasia (TVD) represent uncommon congenital malformations of the tricuspid valve. The purpose of this study is to report on current perinatal outcomes of EA/TVD in our center and to investigate clinical and fetal echocardiographic predictors of perinatal mortality. METHODS AND

RESULTS:

We performed a retrospective study among fetuses diagnosed from January 2014 to December 2023. Clinical and echocardiographic data were obtained from hospital records of Research and Education Hospital. The primary outcome was perinatal mortality. Of 21 fetuses diagnosed, there were 1 lost to follow-up, 1 termination, and 7 demises. In the live-born cohort of 12 live-born patients, 2 died before discharge, yielding an overall perinatal mortality of 50%. The median gestational age at diagnosis was 23 for non-survivors and 24 weeks for survivors. Birth weight was lower in non-survivors (2430 g vs 2990 g). Tricuspid insufficiency severity varied insignificantly. Non-survivors exhibited higher rates of hydrops, functional atresia, and absent antegrade flow (p < 0.05). Two infants with severe tricuspid insufficiency and congenital abnormalities died postnatally. The limited dataset enables further analysis for a predictive model. Notably, all non-survivors displayed hydrops, functional atresia, and absent antegrade flow, hindering definitive determination of the most impactful parameter on survival estimation.

CONCLUSION:

Perinatal mortality remains notably elevated in fetuses with EA/TVD. The individuals at the highest risk are those with antegrade flow loss and functional atresia of pulmonary valve, this high-risk subgroup could benefit from targeted interventions, such as novel prenatal therapies or a more comprehensive perinatal approach involving optimized timing of delivery and postnatal interventional strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Válvula Tricúspide / Ecocardiografía / Ultrasonografía Prenatal / Anomalía de Ebstein / Mortalidad Perinatal Límite: Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Válvula Tricúspide / Ecocardiografía / Ultrasonografía Prenatal / Anomalía de Ebstein / Mortalidad Perinatal Límite: Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Alemania