Association of monocyte to HDL cholesterol ratio and a composite risk score with left ventricular aneurysm formation in patients with acute ST-segment elevation myocardial infarction.
Coron Artery Dis
; 35(6): 490-497, 2024 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-38682446
ABSTRACT
BACKGROUND:
Left ventricular aneurysm (LVA) is an important complication of acute myocardial infarction. This study aimed to investigate the potential predictive value of the monocyte count to high-density lipoprotein cholesterol ratio (MHR) and a composite risk score in determining the formation of LVA in patients with acute ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention.METHODS:
We recruited 1005 consecutive patients with STEMI. Multivariable logistic regression analysis was conducted identify the independent risk factors for LVA formation. Predictive power of MHR and composite risk score for LVA formation were assessed using receiver operating characteristic curve analysis.RESULTS:
The MHR was significantly higher among patients with LVA compared to those without LVA [6.6 (3.8-10.8) vs. 4.6 (3.3-6.3), P â <â 0.001]. Univariable logistic regression analysis revealed that MHR (ORâ =â 3.866, 95% CIâ =â 2.677-5.582, P â <â 0.001) was associated with the risk of LVA formation. The predictive value of MHR remained significant even after multivariate logistic regression analysis [odds ratio (OR)â =â 4.801, 95% confidence interval (CI)â =â 2.672-8.629, P â <â 0.001]. The discriminant power of MHR for LVA is 0.712, which is superior to both monocyte ( C statisticâ =â 0.553) and high-density lipoprotein cholesterol ( C statisticâ =â 0.654). The composite risk score including MHR, gender, LVEF, hemoglobin, lymphocyte and left anterior descending artery as the culprit vessel could significantly increase the predictive ability ( C statisticâ =â 0.920).CONCLUSION:
A higher MHR could effectively identify individuals at high risk of LVA formation, especially when combined with gender, LVEF, hemoglobin, lymphocyte and left anterior descending artery as the culprit vessel.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Monocitos
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Biomarcadores
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Valor Predictivo de las Pruebas
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Intervención Coronaria Percutánea
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Infarto del Miocardio con Elevación del ST
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Aneurisma Cardíaco
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HDL-Colesterol
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Coron Artery Dis
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido