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Microbial Translocation and Gut Damage Are Associated With an Elevated Fast Score in Women Living With and Without HIV.
Duarte, Maria J; Tien, Phyllis C; Kardashian, Ani; Ma, Yifei; Hunt, Peter; Kuniholm, Mark H; Adimora, Adaora A; Fischl, Margaret A; French, Audrey L; Topper, Elizabeth; Konkle-Parker, Deborah; Minkoff, Howard; Ofotokun, Ighovwerha; Plankey, Michael; Sharma, Anjali; Price, Jennifer C.
Afiliación
  • Duarte MJ; Division of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Tien PC; Department of Veterans Affairs Medical Center and Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Kardashian A; Division of Gastroenterology and Liver Diseases, University of Southern California, Los Angeles, California, USA.
  • Ma Y; Department of Veterans Affairs Medical Center and Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Hunt P; Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA.
  • Kuniholm MH; Department of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, New York, USA.
  • Adimora AA; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Fischl MA; Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA.
  • French AL; Department of Medicine, CORE Center/Stroger Hospital of Cook County, Chicago, Illinois, USA.
  • Topper E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Konkle-Parker D; School of Nursing, Medicine and Population Health, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Minkoff H; Department of Obstetrics and Gynecology, Downstate Health Sciences University, State University of New York, Brooklyn, New York, USA.
  • Ofotokun I; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.
  • Plankey M; Department of Medicine, Georgetown University Medical Center, Washington, DC, USA.
  • Sharma A; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Price JC; Division of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Open Forum Infect Dis ; 11(5): ofae187, 2024 May.
Article en En | MEDLINE | ID: mdl-38680610
ABSTRACT

Background:

Steatohepatitis is common in persons living with HIV and may be associated with gut microbial translocation (MT). However, few studies have evaluated the gut-liver axis in persons living with HIV. In the Women's Interagency HIV Study, we examined the associations of HIV and circulating biomarkers linked to MT and gut damage using the FibroScan-aspartate aminotransferase (FAST) score, a noninvasive surrogate for steatohepatitis with advanced fibrosis.

Methods:

Among 883 women with HIV and 354 without HIV, we used multivariable regression to examine the associations of HIV and serum biomarkers linked to MT and gut damage (kynurenine and tryptophan ratio, intestinal fatty acid-binding protein, soluble CD14, and soluble CD163) with a log-transformed FAST score after adjusting for key covariates. We used a path analysis and mediation models to determine the mediating effect of each biomarker on the association of HIV with FAST.

Results:

HIV infection was associated with a 49% higher FAST score. MT biomarker levels were higher in women with HIV than women without HIV (P < .001 for each). MT biomarkers mediated 13% to 32% of the association of HIV and FAST score.

Conclusions:

Biomarkers linked to MT and gut damage are associated with a higher FAST score and mediate the association of HIV with a higher FAST score. Our findings suggest that MT may be an important mechanism by which HIV increases the risk of steatohepatitis with advanced fibrosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos