Identification of ACAA1 and HADHB as potential prognostic biomarkers based on a novel fatty acid oxidation-related gene model in head and neck squamous cell carcinoma: A retrospective study.

Wang, Wan-Li; Jiang, Hong-Jie; Shen, Ze-Liang; Tang, Ya-Ling; Jiang, Jian; Liang, Xin-Hua

Wang, Wan-Li; Jiang, Hong-Jie; Shen, Ze-Liang; Tang, Ya-Ling; Jiang, Jian; Liang, Xin-Hua.

Afiliación

Wang WL; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: 15139475085@163.com.
Jiang HJ; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: hongjzai@163.com.
Shen ZL; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: aaronshenzeliang@163.com.
Tang YL; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: tangyaling@scu.edu.cn.
Jiang J; Department of Head and Neck Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China. Electronic address: jiangjianswc@163.com.
Liang XH; State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: lxh88866@scu.edu.cn.

Arch Oral Biol ; 163: 105982, 2024 Jul.

Article en En | MEDLINE | ID: mdl-38678878

ABSTRACT

ABSTRACT

OBJECTIVES:

To investigate the importance of fatty acid oxidation (FAO)-related genes in predicting the progression and prognosis of head and neck squamous cell carcinoma (HNSCC).

METHODS:

The FAO-related gene prognostic model was established employing Cox regression analyses, during which accuracy and sensitivity of the gene model were evaluated in The Cancer Genome Atlas (TCGA) internal testing and Gene Expression Omnibus (GEO) external validation cohorts. Ultimately, hub genes were identified among 13 model genes using STRING and Cytoscape, with preliminary validation carried out through immunohistochemistry.

RESULTS:

The model, which comprised 13 genes (ABCD2, ACAA1, ACACB, AKT1, CNR1, CPT1C, CROT, ECHDC2, ETFA, HADHB, IRS2, LONP2, and SLC25A17), was established. On the basis of the median risk score, the two cohorts were grouped into low-and high-risk groups in the subsequent test and validation, and the former exhibited significantly higher survival rates than the latter. Nomograms were established based on prognostic factors, including stage and risk score, and individualized for the prediction of HNSCC patients. Ultimately, immunohistochemical staining showed that ACAA1 and HADHB were significantly under-expressed in HNSCC, with a favorable prognosis associated with low HADHB and high ACAA1.

CONCLUSIONS:

The gene prognostic model has illustrated promising capability in predicting the prognosis, and ACAA1 and HADHB might serve as potential therapeutic biomarkers for HNSCC patients.

Asunto(s)

Biomarcadores de Tumor; Ácidos Grasos; Neoplasias de Cabeza y Cuello; Carcinoma de Células Escamosas de Cabeza y Cuello; Anciano; Femenino; Humanos; Masculino; Persona de Mediana Edad; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Ácidos Grasos/metabolismo; Regulación Neoplásica de la Expresión Génica; Neoplasias de Cabeza y Cuello/genética; Neoplasias de Cabeza y Cuello/metabolismo; Inmunohistoquímica; Nomogramas; Oxidación-Reducción; Pronóstico; Estudios Retrospectivos; Carcinoma de Células Escamosas de Cabeza y Cuello/genética; Carcinoma de Células Escamosas de Cabeza y Cuello/metabolismo; Carcinoma de Células Escamosas de Cabeza y Cuello/patología

Palabras clave

Fatty acid oxidation; Gene prognostic model; Head and neck squamous cell carcinoma; Immunohistochemical staining

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Ácidos Grasos / Carcinoma de Células Escamosas de Cabeza y Cuello / Neoplasias de Cabeza y Cuello Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Oral Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

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