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Exclusion of HDAC1/2 complexes by oncogenic nuclear condensates.
Kuang, Junqi; Li, Pengli; Zhai, Ziwei; Fan, Yixin; Xu, HuaiYuan; Zhao, Chengchen; Li, Wei; Li, Xiaoxi; Liang, Zechuan; Huang, Tao; Qin, Yue; Gao, Huiru; Ma, Zhaoyi; Liu, Dong; Zhong, Guifa; Wang, Bo; Liu, Jing; Wang, Jin; Tortorella, Micky D; Liao, Baojian; Pei, Duanqing.
Afiliación
  • Kuang J; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.
  • Li P; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China.
  • Zhai Z; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, Zhejiang, China.
  • Fan Y; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Xu H; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Zhao C; University of Chinese Academy of Sciences, Beijing, China.
  • Li W; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Li X; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Liang Z; University of Chinese Academy of Sciences, Beijing, China.
  • Huang T; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Qin Y; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Gao H; University of Chinese Academy of Sciences, Beijing, China.
  • Ma Z; Department of Musculoskeletal Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.
  • Liu D; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.
  • Zhong G; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Wang B; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Liu J; University of Chinese Academy of Sciences, Beijing, China.
  • Wang J; CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Tortorella MD; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Liao B; University of Chinese Academy of Sciences, Beijing, China.
  • Pei D; Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.
Mol Cancer ; 23(1): 85, 2024 Apr 27.
Article en En | MEDLINE | ID: mdl-38678233
ABSTRACT
Nuclear condensates have been shown to regulate cell fate control, but its role in oncogenic transformation remains largely unknown. Here we show acquisition of oncogenic potential by nuclear condensate remodeling. The proto-oncogene SS18 and its oncogenic fusion SS18-SSX1 can both form condensates, but with drastically different properties and impact on 3D genome architecture. The oncogenic condensates, not wild type ones, readily exclude HDAC1 and 2 complexes, thus, allowing aberrant accumulation of H3K27ac on chromatin loci, leading to oncogenic expression of key target genes. These results provide the first case for condensate remodeling as a transforming event to generate oncogene and such condensates can be targeted for therapy. One sentence

summary:

Expulsion of HDACs complexes leads to oncogenic transformation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histona Desacetilasa 1 / Histona Desacetilasa 2 / Proto-Oncogenes Mas Límite: Animals / Humans Idioma: En Revista: Mol Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histona Desacetilasa 1 / Histona Desacetilasa 2 / Proto-Oncogenes Mas Límite: Animals / Humans Idioma: En Revista: Mol Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido