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Low absolute risk of thrombotic and cardiovascular events in outpatient pregnant women with COVID-19.
Bikdeli, Behnood; Krishnathasan, Darsiya; Khairani, Candrika D; Bejjani, Antoine; Davies, Julia; Porio, Nicole; Tristani, Anthony; Armero, Andre; Assi, Ali A; Nauffal, Victor; Campia, Umberto; Almarzooq, Zaid; Wei, Eric; Ortiz-Rios, Marcos D; Zuluaga-Sánchez, Valeria; Achanta, Aditya; Jesudasen, Sirus J; Tiu, Bruce; Merli, Geno J; Leiva, Orly; Fanikos, John; Grandone, Elvira; Sharma, Aditya; Rizzo, Samantha; Pfeferman, Mariana B; Morrison, Ruth B; Vishnevsky, Alec; Hsia, Judith; Nehler, Mark R; Welker, James; Bonaca, Marc P; Carroll, Brett; Goldhaber, Samuel Z; Lan, Zhou; Piazza, Gregory.
Afiliación
  • Bikdeli B; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA; YNHH/ Yale Center for Outcomes Research and Evaluation (CORE), New Haven, CT, USA; Cardiovascular Research Foundation (CR
  • Krishnathasan D; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Khairani CD; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Bejjani A; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Davies J; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Porio N; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Tristani A; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Armero A; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Assi AA; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Nauffal V; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Campia U; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Almarzooq Z; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Wei E; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Ortiz-Rios MD; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Zuluaga-Sánchez V; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Achanta A; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Jesudasen SJ; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Tiu B; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Merli GJ; Department of Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
  • Leiva O; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Fanikos J; Department of Pharmacy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Grandone E; Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", S. Giovanni Rotondo (Foggia), Italy; Department of Obstetrics and Gynecology, First I.M. Sechenov Moscow State Medical University, Moscow, Russia.
  • Sharma A; Department of Medicine, Cardiovascular Medicine, University of Virginia Health, Charlottesville, VA, USA.
  • Rizzo S; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Pfeferman MB; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Morrison RB; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Vishnevsky A; Department of Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
  • Hsia J; CPC Clinical Research, Aurora, CO, USA; Department of Medicine, University of Colorado, Aurora, CO, USA.
  • Nehler MR; CPC Clinical Research, Aurora, CO, USA.
  • Welker J; Anne Arundel Research Institute, Annapolis, MD, USA.
  • Bonaca MP; CPC Clinical Research, Aurora, CO, USA; Department of Medicine, University of Colorado, Aurora, CO, USA.
  • Carroll B; Smith Center for Cardiovascular Outcomes Research, Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Goldhaber SZ; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA.
  • Lan Z; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA; Center for Clinical Investigation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Piazza G; Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, USA. Electronic address: gpiazza@bwh.harvard.edu.
Thromb Res ; 237: 209-215, 2024 May.
Article en En | MEDLINE | ID: mdl-38677791
ABSTRACT

INTRODUCTION:

Pregnancy may contribute to an excess risk of thrombotic or cardiovascular events. COVID-19 increases the risk of these events, although the risk is relatively limited among outpatients. We sought to determine whether outpatient pregnant women with COVID-19 are at a high risk for cardiovascular or thrombotic events. MATERIALS &

METHODS:

We analyzed pregnant outpatients with COVID-19 from the multicenter CORONA-VTE-Network registry. The main study outcomes were a composite of adjudicated venous or arterial thrombotic events, and a composite of adjudicated cardiovascular events. Events were assessed 90 days after the COVID-19 diagnosis and reported for non-pregnant women ≤45 years, and for men ≤45 years, as points of reference.

RESULTS:

Among 6585 outpatients, 169 were pregnant at diagnosis. By 90-day follow-up, two pregnant women during the third trimester had lower extremity venous thrombosis, one deep and one superficial vein thrombosis. The cumulative incidence of thrombotic events was 1.20 % (95 % confidence interval [CI] 0.0 to 2.84 %). Respective rates were 0.47 % (95 % CI 0.14 % to 0.79 %) among non-pregnant women, and 0.49 % (95 % CI 0.06 % to 0.91 %) among men ≤45 years. No non-thrombotic cardiovascular events occurred in pregnant women. The rates of cardiovascular events were 0.53 % (95 % CI 0.18 to 0.87) among non-pregnant women, and 0.68 % (95 % CI 0.18 to 1.18) in men aged ≤45 years.

CONCLUSIONS:

Thrombotic and cardiovascular events are rare among outpatients with COVID-19. Although a higher event rate among outpatient pregnant women cannot be excluded, the absolute event rates are low and do not warrant population-wide cardiovascular interventions to optimize outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pacientes Ambulatorios / Trombosis / COVID-19 Límite: Adult / Female / Humans / Male / Middle aged / Pregnancy Idioma: En Revista: Thromb Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pacientes Ambulatorios / Trombosis / COVID-19 Límite: Adult / Female / Humans / Male / Middle aged / Pregnancy Idioma: En Revista: Thromb Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos