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Clinical Evaluation of the BIOFIRE SPOTFIRE Respiratory Panel.
Chan, Wai-Sing; Ho, Christy Wing-Yiu; Chan, Tsz-Ching; Hung, Jeffrey; To, Man-Yan; Leung, Sau-Man; Lai, Ka-Chun; Wong, Ching-Yan; Leung, Chin-Pang; Au, Chun-Hang; Wan, Thomas Shek-Kong; Zee, Jonpaul Sze-Tsing; Ma, Edmond Shiu-Kwan; Tang, Bone Siu-Fai.
Afiliación
  • Chan WS; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Ho CW; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Chan TC; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Hung J; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • To MY; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Leung SM; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Lai KC; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Wong CY; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Leung CP; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Au CH; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Wan TS; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Zee JS; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Ma ES; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
  • Tang BS; Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong SAR, China.
Viruses ; 16(4)2024 04 13.
Article en En | MEDLINE | ID: mdl-38675941
ABSTRACT
The BIOFIRE SPOTFIRE Respiratory (R) Panel is a novel, in vitro diagnostic PCR assay with 15 pathogen targets. The runtime is about 15 min which is the shortest among similar panels in the market. We evaluated the performance of the SPOTFIRE R Panel with 151 specimens, including 133 collected from the upper respiratory tract (URT), 13 from the lower respiratory tract (LRT) and 5 external quality assessment program (EQAP) samples. The respiratory specimens were enrolled throughout the first two post-COVID-19 influenza seasons in Hong Kong (March to December 2023). For URT specimens, full concordance was observed between the SPOTFIRE R Panel and the standard-of-care FilmArray Respiratory 2.1 plus Panel (RP2.1plus) for 109 specimens (109/133, 81.95%). After discrepant analysis, the SPOTFIRE R Panel identified more pathogens than the RP2.1plus in 15 specimens and vice versa in 3 specimens. The per-target negative and positive percentage agreement (NPA and PPA) were 92.86-100% except the PPA of adenovirus (88.24%). For LRT and EQAP samples, all results were fully concordant. To conclude, the performance of the SPOTFIRE R Panel was comparable to the RP2.1plus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / SARS-CoV-2 / COVID-19 Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Viruses Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / SARS-CoV-2 / COVID-19 Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Viruses Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza