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A Variety of Mouse PYHIN Proteins Restrict Murine and Human Retroviruses.
Erdemci-Evin, Sümeyye; Bosso, Matteo; Krchlikova, Veronika; Bayer, Wibke; Regensburger, Kerstin; Mayer, Martha; Dittmer, Ulf; Sauter, Daniel; Kmiec, Dorota; Kirchhoff, Frank.
Afiliación
  • Erdemci-Evin S; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Bosso M; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Krchlikova V; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, 72076 Tübingen, Germany.
  • Bayer W; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
  • Regensburger K; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Mayer M; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Dittmer U; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
  • Sauter D; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, 72076 Tübingen, Germany.
  • Kmiec D; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Viruses ; 16(4)2024 03 23.
Article en En | MEDLINE | ID: mdl-38675836
ABSTRACT
PYHIN proteins are only found in mammals and play key roles in the defense against bacterial and viral pathogens. The corresponding gene locus shows variable deletion and expansion ranging from 0 genes in bats, over 1 in cows, and 4 in humans to a maximum of 13 in mice. While initially thought to act as cytosolic immune sensors that recognize foreign DNA, increasing evidence suggests that PYHIN proteins also inhibit viral pathogens by more direct mechanisms. Here, we examined the ability of all 13 murine PYHIN proteins to inhibit HIV-1 and murine leukemia virus (MLV). We show that overexpression of p203, p204, p205, p208, p209, p210, p211, and p212 strongly inhibits production of infectious HIV-1; p202, p207, and p213 had no significant effects, while p206 and p214 showed intermediate phenotypes. The inhibitory effects on infectious HIV-1 production correlated significantly with the suppression of reporter gene expression by a proviral Moloney MLV-eGFP construct and HIV-1 and Friend MLV LTR luciferase reporter constructs. Altogether, our data show that the antiretroviral activity of PYHIN proteins is conserved between men and mice and further support the key role of nuclear PYHIN proteins in innate antiviral immunity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfoproteínas / VIH-1 / Virus de la Leucemia Murina Límite: Animals / Humans Idioma: En Revista: Viruses Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfoproteínas / VIH-1 / Virus de la Leucemia Murina Límite: Animals / Humans Idioma: En Revista: Viruses Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza