The Repellent Capacity against <i>Sitophilus zeamais</i> (Coleoptera: Curculionidae) and <i>In Vitro</i> Inhibition of the Acetylcholinesterase Enzyme of 11 Essential Oils from Six Plants of the Caribbean Region of Colombia.

Muñoz-Acevedo, Amner; González, María C; Alonso, Jesús E; Flórez, Karen C

The Repellent Capacity against Sitophilus zeamais (Coleoptera: Curculionidae) and In Vitro Inhibition of the Acetylcholinesterase Enzyme of 11 Essential Oils from Six Plants of the Caribbean Region of Colombia.

Muñoz-Acevedo, Amner; González, María C; Alonso, Jesús E; Flórez, Karen C.

Afiliación

Muñoz-Acevedo A; Department of Chemistry and Biology, Universidad del Norte, Puerto Colombia 081007, Colombia.
González MC; Department of Chemistry and Biology, Universidad del Norte, Puerto Colombia 081007, Colombia.
Alonso JE; Department of Mathematics and Statistics, Universidad del Norte, Puerto Colombia 081007, Colombia.
Flórez KC; Department of Mathematics and Statistics, Universidad del Norte, Puerto Colombia 081007, Colombia.

Molecules ; 29(8)2024 Apr 12.

Article en En | MEDLINE | ID: mdl-38675573

ABSTRACT

ABSTRACT

The repellent capacity against Sitophilus zeamais and the in vitro inhibition on AChE of 11 essential oils, isolated from six plants of the northern region of Colombia, were assessed using a modified tunnel-type device and the Ellman colorimetric method, respectively. The results were as follows (i) the degree of repellency (DR) of the EOs against S. zeamais was 20-68% (2 h) and 28-74% (4 h); (ii) the IC50 values on AChE were 5-36 µg/mL; likewise, the %inh. on AChE (1 µg/cm3 per EO) did not show any effect in 91% of the EO tested; (iii) six EOs (Bursera graveolens-bark, B. graveolens-leaves, B. simaruba-bark, Peperomia pellucida-leaves, Piper holtonii (1b*)-leaves, and P. reticulatum-leaves) exhibited a DR (53-74%) ≥ C+ (chlorpyrifos-61%), while all EOs were less active (8-60-fold) on AChE compared to chlorpyrifos (IC50 of 0.59 µg/mL). Based on the ANOVA/linear regression and multivariate analysis of data, some differences/similarities could be established, as well as identifying the most active EOs (five B. simaruba-bark, Pep. Pellucida-leaves, P. holtonii (1b*)-leaves, B. graveolens-bark, and B. graveolens-leaves). Finally, these EOs were constituted by spathulenol (24%)/ß-selinene (18%)/caryophyllene oxide (10%)-B. simaruba; carotol (44%)/dillapiole (21%)-Pep. pellucida; dillapiole (81% confirmed by 1H-/13C-NMR)-P. holtonii; mint furanone derivative (14%)/mint furanone (14%)-B. graveolens-bark; limonene (17%)/carvone (10%)-B. graveolens-leaves.

Asunto(s)

Inhibidores de la Colinesterasa; Repelentes de Insectos; Aceites Volátiles; Sesquiterpenos Policíclicos; Animales; Acetilcolinesterasa/metabolismo; Inhibidores de la Colinesterasa/farmacología; Inhibidores de la Colinesterasa/química; Colombia; Repelentes de Insectos/farmacología; Repelentes de Insectos/química; Aceites Volátiles/farmacología; Aceites Volátiles/química; Piper/química; Aceites de Plantas/farmacología; Aceites de Plantas/química; Sesquiterpenos Policíclicos/química; Sesquiterpenos Policíclicos/farmacología; Gorgojos/enzimología; Gorgojos/efectos de los fármacos; Sesquiterpenos de Eudesmano/química; Sesquiterpenos de Eudesmano/farmacología; Sesquiterpenos/química; Sesquiterpenos/farmacología

Palabras clave

AChE inhibition; Colombian essential oils; maize; maize weevil; post-harvest protection; repellency

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites Volátiles / Inhibidores de la Colinesterasa / Sesquiterpenos Policíclicos / Repelentes de Insectos Límite: Animals País/Región como asunto: America do sul / Colombia Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Colombia Pais de publicación: Suiza

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