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Human Milk Oligosaccharides, Growth, and Body Composition in Very Preterm Infants.
Ong, Margaret L; Cherkerzian, Sara; Bell, Katherine A; Berger, Paige K; Furst, Annalee; Sejane, Kristija; Bode, Lars; Belfort, Mandy B.
Afiliación
  • Ong ML; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Cherkerzian S; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Bell KA; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Berger PK; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Furst A; Department of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), Human Milk Institute (HMI), University of California San Diego, La Jolla, CA 92093, USA.
  • Sejane K; Department of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), Human Milk Institute (HMI), University of California San Diego, La Jolla, CA 92093, USA.
  • Bode L; Department of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), Human Milk Institute (HMI), University of California San Diego, La Jolla, CA 92093, USA.
  • Belfort MB; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Nutrients ; 16(8)2024 Apr 18.
Article en En | MEDLINE | ID: mdl-38674890
ABSTRACT
Human milk oligosaccharides (HMOs) are bioactive factors that benefit neonatal health, but little is known about effects on growth in very preterm infants (<32 weeks' gestation). We aimed to quantify HMO concentrations in human milk fed to very preterm infants during the neonatal hospitalization and investigate associations of HMOs with infant size and body composition at term-equivalent age. In 82 human-milk-fed very preterm infants, we measured HMO concentrations at two time points. We measured anthropometrics and body composition with air displacement plethysmography at term-equivalent age. We calculated means of individual and total HMOs, constructed tertiles of mean HMO concentrations, and assessed differences in outcomes comparing infants in the highest and intermediate tertiles with the lowest tertile using linear mixed effects models, adjusted for potential confounders. The mean (SD) infant gestational age was 28.2 (2.2) weeks, and birthweight was 1063 (386) grams. Exposure to the highest (vs. lowest) tertile of HMO concentrations was not associated with anthropometric or body composition z-scores at term-corrected age. Exposure to the intermediate (vs. lowest) tertile of 3FL was associated with a greater head circumference z-score (0.61, 95% CI 0.15, 1.07). Overall, the results do not support that higher HMO intakes influence growth outcomes in this very preterm cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Composición Corporal / Edad Gestacional / Leche Humana Límite: Female / Humans / Male / Newborn Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Composición Corporal / Edad Gestacional / Leche Humana Límite: Female / Humans / Male / Newborn Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza