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Study on Nocturnal Infant Crying Evaluation (NICE) and Reflux Disease (RED).
Carabelli, Greta; Binotto, Ivan; Armano, Chiara; Bertù, Lorenza; Luini, Chiara; Nosetti, Luana; Agosti, Massimo; Salvatore, Silvia.
Afiliación
  • Carabelli G; Pediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
  • Binotto I; Pediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
  • Armano C; Pediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
  • Bertù L; Research Center Tromboembolic Diseases, University of Insubria, 21100 Varese, Italy.
  • Luini C; Pediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
  • Nosetti L; Pediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
  • Agosti M; Pediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
  • Salvatore S; Pediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
Children (Basel) ; 11(4)2024 Apr 08.
Article en En | MEDLINE | ID: mdl-38671666
ABSTRACT

BACKGROUND:

Nocturnal infant crying is often empirically treated with acid suppressants. The aim of this study was to evaluate the prevalence and characteristics of gastroesophageal reflux (GER) in infants with unexplained persistent crying.

METHODS:

We enrolled all infants (0-12 months) referred for suspected GER disease who underwent esophageal impedance-pH monitoring (MII-pH) for unexplained persistent crying not improved by parental reassurance, dietary modification or alginate. Gastrointestinal malformation/surgery, neurological impairment and infections were exclusion criteria. Demographic and anthropometric parameters, GER symptoms and questionnaires (I-GERQ-R) and MII-pH data were recorded and analyzed. Normal MII-pH was defined when acid exposure was <3%, symptom index was <50% and symptom association probability was <95%. Acid exposure >5% and >10% was also considered. Statistical analysis was performed using Chi-Square and univariate and multivariable regression analysis.

RESULTS:

We included 50 infants (median age 3.5 months) who fulfilled the study criteria 30 (60%) had normal MII-pH. I-GERQ-R score was abnormal in 33 (66%) infants, and 21/33 (64%) had normal MII-pH (p = 0.47). In the 26 (52%) infants with nocturnal crying, MII-pH was normal in 16 (54%) (p = 0.82). Associated regurgitation (>3 or >10 episodes/die) did not predict abnormal MII-pH (p = 0.74, p = 0.82, respectively). Univariate and multivariable regression analysis did not identify any clinical variable significantly associated with abnormal MII-pH.

CONCLUSIONS:

Infants with persistent unexplained and nocturnal crying should not be empirically treated with acid inhibitors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Children (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Children (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza