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To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis.
Resende, Gustavo Gomes; Saad, Carla Goncalves Schahin; Marques, Claudia Diniz Lopes; Ribeiro, Sandra Lúcia Euzébio; de Oliveira Gavi, Maria Bernadete Renoldi; Yazbek, Michel Alexandre; de Oliveira Marinho, Adriana; de Cássia Menin, Rita; Ochtrop, Manuella Lima Gomes; Soares, Andressa Miozzo; Cavalcanti, Nara Gualberto; Carneiro, Jamille Nascimento; Werner de Castro, Glaucio Ricardo; Fernandes, José Mauro Carneiro; da Cruz Ribeiro E Souza, Elziane; de Menezes Alvarenga, Corina Quental; de Abreu Vieira, Rejane Maria Rodrigues; Machado, Natalia Pereira; Ximenes, Antônio Carlos; Gazzeta, Morgana Ohira; de Albuquerque, Cleandro Pires; Skare, Thelma Larocca; Waldemar Keiserman, Mauro; Kohem, Charles Lubianca; Benacon, Gabriel Sarkis; Rocha, Vítor Florêncio Santos; da Cruz Lage, Ricardo; Malheiro, Olivio Brito; Golebiovski, Rywka Tenenbaum Medeiros; Oliveira, Thauana Luiza; Duque, Ruben Horst; Londe, Ana Carolina; de Medeiros Pinheiro, Marcelo; Sampaio-Barros, Percival Degrava.
Afiliación
  • Resende GG; Hospital das Clínicas da UFMG, Belo Horizonte, Brazil. gustavogomesresende@yahoo.com.br.
  • Saad CGS; Serviço de Reumatologia do Hospital das Clínicas da Universidade Federal de Minas Gerais, Alameda Álvaro Celso, 175/2nd floor, Santa Efigênia, Belo Horizonte, MG, Brazil. gustavogomesresende@yahoo.com.br.
  • Marques CDL; Faculdade de Medicina da USP, São Paulo, Brazil.
  • Ribeiro SLE; Hospital das Clínicas da UFPE, Recife, Brazil.
  • de Oliveira Gavi MBR; Faculdade de Medicina da UFAM, Manaus, Brazil.
  • Yazbek MA; Universidade Federal do Espírito Santo, Vitória, Brazil.
  • de Oliveira Marinho A; Universidade Estadual de Campinas, Campinas, Brazil.
  • de Cássia Menin R; Fundação Hospital do Acre, Rio Branco, Brazil.
  • Ochtrop MLG; Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil.
  • Soares AM; Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Cavalcanti NG; Hospital Universitário da UFSC, Florianópolis, Brazil.
  • Carneiro JN; Hospital das Clínicas da UFPE, Recife, Brazil.
  • Werner de Castro GR; Hospital de Base do Distrito Federal, Brasília, Brazil.
  • Fernandes JMC; Hospital Governador Celso Ramos, Florianópolis, Brazil.
  • da Cruz Ribeiro E Souza E; Universidade Federal do Maranhão, São Luís, Brazil.
  • de Menezes Alvarenga CQ; Hospital de Clínicas da UFU, Uberlândia, Brazil.
  • de Abreu Vieira RMR; Santa Casa de Belo Horizonte, Belo Horizonte, Brazil.
  • Machado NP; Universidade Estadual do Ceará, Fortaleza, Brazil.
  • Ximenes AC; Universidade Federal do Paraná, Curitiba, Brazil.
  • Gazzeta MO; Hospital Geral de Goiânia, Goiânia, Brazil.
  • de Albuquerque CP; Santa Casa do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Skare TL; Hospital Universitário de Brasília, Brasília, Brazil.
  • Waldemar Keiserman M; Hospital Universitário Evangélico Mackenzie, Curitiba, Brazil.
  • Kohem CL; Faculdade de Medicina da PUCRS, Porto Alegre, Brazil.
  • Benacon GS; Faculdade de Medicina da UFRGS, Porto Alegre, Brazil.
  • Rocha VFS; Faculdade de Medicina da UFAM, Manaus, Brazil.
  • da Cruz Lage R; Faculdade de Medicina da UFAM, Manaus, Brazil.
  • Malheiro OB; Hospital das Clínicas da UFMG, Belo Horizonte, Brazil.
  • Golebiovski RTM; Hospital das Clínicas da UFMG, Belo Horizonte, Brazil.
  • Oliveira TL; Escola Paulista de Medicina - UNIFESP, São Paulo, Brazil.
  • Duque RH; Escola Paulista de Medicina - UNIFESP, São Paulo, Brazil.
  • Londe AC; Universidade Federal do Espírito Santo, Vitória, Brazil.
  • de Medeiros Pinheiro M; Universidade Estadual de Campinas, Campinas, Brazil.
  • Sampaio-Barros PD; Escola Paulista de Medicina - UNIFESP, São Paulo, Brazil.
Adv Rheumatol ; 64(1): 33, 2024 04 26.
Article en En | MEDLINE | ID: mdl-38671475
ABSTRACT

BACKGROUND:

There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE).

METHODS:

The RBE is a multicenter, observational, prospective cohort that enrolled patients with SpA from 46 centers representing all five geographic regions of Brazil. The inclusion criteria were as follow (1) diagnosis of axSpA by an expert rheumatologist; (2) age ≥18 years; (3) classification according to ASAS axial. The following data were collected via a standardized protocol demographic data, disease parameters and treatment historical.

RESULTS:

A total of 1096 patients were included, with 73.4% HLA-B27 positivity and a mean age of 44.4 (±13.2) years. Positive HLA-B27 was significantly associated with male sex, earlier age at disease onset and diagnosis, uveitis, and family history of SpA. Conversely, negative HLA-B27 was associated with psoriasis, higher peripheral involvement and disease activity, worse quality of life and mobility.

CONCLUSIONS:

Our data showed that HLA-B27 positivity was associated with a classic axSpA pattern quite similar to that of Caucasian axSpA patients around the world. Furthermore, its absence was associated with peripheral manifestations and worse outcomes, suggesting a relevant phenotypic difference in a highly miscegenated population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenotipo / Antígeno HLA-B27 / Sistema de Registros / Espondiloartritis Axial Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Adv Rheumatol Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenotipo / Antígeno HLA-B27 / Sistema de Registros / Espondiloartritis Axial Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Adv Rheumatol Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido