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A practical approach to screening for carbapenemase-producing Enterobacterales- views of a group of multidisciplinary experts from English hospitals.
Jenkins, D R; Auckland, C; Chadwick, C; Dodgson, A R; Enoch, D A; Goldenberg, S D; Hussain, A; Martin, J; Spooner, E; Whalley, T.
Afiliación
  • Jenkins DR; University Hospitals of Leicester NHS Trust, Leicester, UK. david.jenkins@uhl-tr.nhs.uk.
  • Auckland C; Royal Devon & Exeter NHS Foundation Trust, Exeter, UK.
  • Chadwick C; Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
  • Dodgson AR; Manchester University NHS FT, Manchester, UK.
  • Enoch DA; Cambridge University NHS Foundation Trust, Cambridge, UK.
  • Goldenberg SD; Centre for Clinical Infection and Diagnostics Research, Guy's and Saint Thomas' Hospitals NHS Trust, London, UK.
  • Hussain A; University Hospitals Birmingham NHS Foundation Trust, West Midlands, UK.
  • Martin J; Leeds Teaching Hospitals NHS Trust, Leeds, UK.
  • Spooner E; Royal Wolverhampton NHS Trust, Wolverhampton, UK.
  • Whalley T; Lancashire & South Cumbria ICB, Preston, UK.
BMC Infect Dis ; 24(1): 444, 2024 Apr 26.
Article en En | MEDLINE | ID: mdl-38671365
ABSTRACT

INTRODUCTION:

Carbapenemase-producing Enterobacterales (CPE) are an important public health threat, with costly operational and economic consequences for NHS Integrated Care Systems and NHS Trusts. UK Health Security Agency guidelines recommend that Trusts use locally developed risk assessments to accurately identify high-risk individuals for screening, and implement the most appropriate method of testing, but this presents many challenges.

METHODS:

A convenience sample of cross-specialty experts from across England met to discuss the barriers and practical solutions to implementing UK Health Security Agency framework into operational and clinical workflows. The group derived responses to six key questions that are frequently asked about screening for CPE. KEY

FINDINGS:

Four patient groups were identified for CPE screening high-risk unplanned admissions, high-risk elective admissions, patients in high-risk units, and known positive contacts. Rapid molecular testing is a preferred screening method for some of these settings, offering faster turnaround times and more accurate results than culture-based testing. It is important to stimulate action now, as several lessons can be learnt from screening during the COVID-19 pandemic, as well as from CPE outbreaks.

CONCLUSION:

Further decisive and instructive information is needed to establish CPE screening protocols based on local epidemiology and risk factors. Local management should continually evaluate local epidemiology, analysing data and undertaking frequent prevalence studies to understand risks, and prepare resources- such as upscaled screening- to prevent increasing prevalence, clusters or outbreaks. Rapid molecular-based methods will be a crucial part of these considerations, as they can reduce unnecessary isolation and opportunity costs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Beta-Lactamasas / Tamizaje Masivo / Infecciones por Enterobacteriaceae Límite: Humans País/Región como asunto: Europa Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Beta-Lactamasas / Tamizaje Masivo / Infecciones por Enterobacteriaceae Límite: Humans País/Región como asunto: Europa Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido