m6A regulates heterochromatin in mammalian embryonic stem cells.
Curr Opin Genet Dev
; 86: 102196, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38669774
ABSTRACT
As the most well-studied modification in mRNA, m6A has been shown to regulate multiple biological processes, including RNA degradation, processing, and translation. Recent studies showed that m6A modification is enriched in chromatin-associated RNAs and nascent RNAs, suggesting m6A might play regulatory roles in chromatin contexts. Indeed, in the past several years, a number of studies have clarified how m6A and its modulators regulate different types of chromatin states. Specifically, in the past 2-3 years, several studies discovered the roles of m6A and/or its modulators in regulating constitutive and facultative heterochromatin, shedding interesting lights on RNA-dependent heterochromatin formation in mammalian cells. This review will summarize and discuss the mechanisms underlying m6A's regulation in different types of heterochromatin, with a specific emphasis on the regulation in mammalian embryonic stem cells, which exhibit distinct features of multiple heterochromatin marks.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Heterocromatina
/
Células Madre Embrionarias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Asunto de la revista:
GENETICA
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido