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Overview of randomized controlled trials of moderate to severe traumatic brain injury: A systematic review.
Teasell, Robert; Flores-Sandoval, Cecilia; Bateman, Emma A; MacKenzie, Heather M; Sequeira, Keith; Bayley, Mark; Janzen, Shannon.
Afiliación
  • Teasell R; Parkwood Institute Research, Lawson Research Institute, London, ON, Canada.
  • Flores-Sandoval C; Department of Physical Medicine and Rehabilitation, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Bateman EA; Parkwood Institute, St. Joseph's Health Care London, London, ON, Canada.
  • MacKenzie HM; Parkwood Institute Research, Lawson Research Institute, London, ON, Canada.
  • Sequeira K; Parkwood Institute Research, Lawson Research Institute, London, ON, Canada.
  • Bayley M; Department of Physical Medicine and Rehabilitation, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Janzen S; Parkwood Institute, St. Joseph's Health Care London, London, ON, Canada.
NeuroRehabilitation ; 54(4): 509-520, 2024.
Article en En | MEDLINE | ID: mdl-38669488
ABSTRACT

BACKGROUND:

Given the complexity of post-TBI medical, surgical, and rehabilitative care, research is critical to optimize interventions across the continuum of care and improve outcomes for persons with moderate to severe TBI.

OBJECTIVE:

To characterize randomized controlled trials (RCTs) of moderate to severe traumatic brain injury (TBI) in the literature.

METHOD:

Systematic searches of MEDLINE, PubMed, Scopus, CINAHL, EMBASE and PsycINFO for RCTs up to December 2022 inclusive were conducted in accordance with PRISMA guidelines.

RESULTS:

662 RCTs of 91,946 participants published from 1978 to 2022 met inclusion criteria. The number of RCTs published annually has increased steadily. The most reported indicator of TBI severity was the Glasgow Coma Scale (545 RCTs, 82.3%). 432 (65.3%) RCTs focused on medical/surgical interventions while 230 (34.7%) addressed rehabilitation. Medical/surgical RCTs had larger sample sizes compared to rehabilitation RCTs. Rehabilitation RCTs accounted for only one third of moderate to severe TBI RCTs and were primarily conducted in the chronic phase post-injury relying on smaller sample sizes.

CONCLUSION:

Further research in the subacute and chronic phases as well as increasing rehabilitation focused TBI RCTs will be important to optimizing the long-term outcomes and quality of life for persons living with TBI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos Clínicos Controlados Aleatorios como Asunto / Lesiones Traumáticas del Encéfalo Límite: Humans Idioma: En Revista: NeuroRehabilitation Asunto de la revista: NEUROLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos Clínicos Controlados Aleatorios como Asunto / Lesiones Traumáticas del Encéfalo Límite: Humans Idioma: En Revista: NeuroRehabilitation Asunto de la revista: NEUROLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos