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Trends in Non-Tuberculous Mycobacterial Lung Disease and Treatment Outcomes in a Low-Tuberculosis Prevalence Setting: A Retrospective Analysis.
Mohanty, Biplob Kumar; Eagan, Tomas Mikal Lind; Aarli, Bernt Bøgvald; Skutlaberg, Dag Harald; Mustafa, Tehmina.
Afiliación
  • Mohanty BK; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway.
  • Eagan TML; Department of Thoracic Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
  • Aarli BB; Department of Clinical Science, University of Bergen, 5020 Bergen, Norway.
  • Skutlaberg DH; Department of Thoracic Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
  • Mustafa T; Department of Clinical Science, University of Bergen, 5020 Bergen, Norway.
Pathogens ; 13(4)2024 Apr 22.
Article en En | MEDLINE | ID: mdl-38668299
ABSTRACT

BACKGROUND:

Information on the management of non-tuberculous mycobacterial (NTM) lung infection and disease is scarce. The aim of this study was to investigate the trends in NTM lung infections, and the factors associated with the initiation of treatment and treatment outcomes.

METHODS:

A retrospective analysis was carried out on patient medical records from Haukeland University Hospital, Bergen, Norway, from 2000 to 2021.

RESULTS:

Among 154 patients with NTM lung infection, the majority (70%) were older than 65 years, and 49% had an underlying pulmonary comorbidity. The most frequently observed mycobacterial species was M. avium complex (MAC), followed by M. malmoense and M. abscessus. In total, 72 (47%) patients received antibiotic treatment. Patients with high symptom scores, aged below 65, and with MAC infection had more than three times the odds of receiving antibiotic treatment. A favourable response and culture conversion was observed in 53 of 72 (74%) patients. However, 17 (32%) of them had a relapse. Out of 82 patients who did not receive treatment, 45 (55%) had spontaneous culture conversion, and 8 (18%) of them had a relapse. No factor was identified to be significantly associated with a favourable treatment response.

CONCLUSION:

A favourable response to treatment was seen in 74% of patients with a high relapse rate.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pathogens Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pathogens Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Suiza