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Inactivated Flagellin-Containing Vaccine Efficacy against Ovine Enzootic Abortion.
Kruglova, Maria; Nikitin, Nikolai; Evtushenko, Ekaterina; Matveeva, Irina; Mazurov, Aleksandr; Pavlenko, Igor; Popova, Vera; Bogomolova, Olesya; Vasilyev, Stepan; Markova, Evgeniya; Fedorov, Yuri.
Afiliación
  • Kruglova M; All-Russian Scientific Research and Technological Institute of Biological Industry, Biocombinat, 141142 Moscow, Russia.
  • Nikitin N; Department of Virology, Lomonosov Moscow State University, 119234 Moscow, Russia.
  • Evtushenko E; Department of Virology, Lomonosov Moscow State University, 119234 Moscow, Russia.
  • Matveeva I; All-Russian Scientific Research and Technological Institute of Biological Industry, Biocombinat, 141142 Moscow, Russia.
  • Mazurov A; All-Russian Scientific Research and Technological Institute of Biological Industry, Biocombinat, 141142 Moscow, Russia.
  • Pavlenko I; All-Russian Scientific Research and Technological Institute of Biological Industry, Biocombinat, 141142 Moscow, Russia.
  • Popova V; All-Russian Scientific Research and Technological Institute of Biological Industry, Biocombinat, 141142 Moscow, Russia.
  • Bogomolova O; All-Russian Scientific Research and Technological Institute of Biological Industry, Biocombinat, 141142 Moscow, Russia.
  • Vasilyev S; All-Russian Scientific Research and Technological Institute of Biological Industry, Biocombinat, 141142 Moscow, Russia.
  • Markova E; All-Russian Scientific Research and Technological Institute of Biological Industry, Biocombinat, 141142 Moscow, Russia.
  • Fedorov Y; All-Russian Scientific Research and Technological Institute of Biological Industry, Biocombinat, 141142 Moscow, Russia.
Pathogens ; 13(4)2024 Mar 24.
Article en En | MEDLINE | ID: mdl-38668231
ABSTRACT
Chlamydia abortus is the etiological agent of abortion and fetal loss in sheep, goats and bovine cattle in many countries. Even though commercially available vaccines can reduce the incidence in sheep, the development of new, safe, and effective vaccines remains high on the agenda. In this study, an evaluation was made of the efficacy of a vaccine candidate, an inactivated antigen based on the extract of outer membrane proteins of a C. abortus strain known as Chlamydia VNITIBP-21, in combination with recombinant flagellin as an adjuvant. Pregnant sheep (n = 43) were divided into three groups an experimental vaccinated group, a control infected group and a control non-infected group. The sheep were vaccinated twice, with an interval of 3 weeks, then infected with the homologous virulent strain of Chlamydia abortus on pregnancy day 75. The vaccine candidate reduced C. abortus shedding in vaginal swabs considerably, in comparison with the control group. In addition, ewes in the experimental group experienced no abortions, while those in the control group experienced instances of abortion, as well as births of weak and nonviable lambs. The findings show that the vaccine candidate proved itself to be promising in combatting the agent of ovine abortion and fetal loss.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pathogens Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pathogens Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza