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Real-World Outcomes of Patients with Advanced Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer in Canada Using Data Extracted by Large Language Model-Based Artificial Intelligence.
Moulson, Ruth; Law, Jennifer; Sacher, Adrian; Liu, Geoffrey; Shepherd, Frances A; Bradbury, Penelope; Eng, Lawson; Iczkovitz, Sandra; Abbie, Erica; Elia-Pacitti, Julia; Ewara, Emmanuel M; Mokriak, Viktoriia; Weiss, Jessica; Pettengell, Christopher; Leighl, Natasha B.
Afiliación
  • Moulson R; Pentavere, 460 College Street, Toronto, ON M6G 1A1, Canada.
  • Law J; Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Sacher A; Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Liu G; Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Shepherd FA; Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Bradbury P; Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Eng L; Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Iczkovitz S; Janssen Inc., Toronto, ON M3C 1L9, Canada.
  • Abbie E; Janssen Inc., Toronto, ON M3C 1L9, Canada.
  • Elia-Pacitti J; Janssen Inc., Toronto, ON M3C 1L9, Canada.
  • Ewara EM; Janssen Inc., Toronto, ON M3C 1L9, Canada.
  • Mokriak V; Pentavere, 460 College Street, Toronto, ON M6G 1A1, Canada.
  • Weiss J; Pentavere, 460 College Street, Toronto, ON M6G 1A1, Canada.
  • Pettengell C; Pentavere, 460 College Street, Toronto, ON M6G 1A1, Canada.
  • Leighl NB; Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Curr Oncol ; 31(4): 1947-1960, 2024 04 02.
Article en En | MEDLINE | ID: mdl-38668049
ABSTRACT
Real-world evidence for patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC) in Canada is limited. This study's objective was to use previously validated DARWENTM artificial intelligence (AI) to extract data from electronic heath records of patients with non-squamous NSCLC at University Health Network (UHN) to describe EGFR mutation prevalence, treatment patterns, and outcomes. Of 2154 patients with NSCLC, 613 had advanced disease. Of these, 136 (22%) had common sensitizing EGFR mutations (cEGFRm; ex19del, L858R), 8 (1%) had exon 20 insertions (ex20ins), and 338 (55%) had EGFR wild type. One-year overall survival (OS) (95% CI) for patients with cEGFRm, ex20ins, and EGFR wild type tumours was 88% (83, 94), 100% (100, 100), and 59% (53, 65), respectively. In total, 38% patients with ex20ins received experimental ex20ins targeting treatment as their first-line therapy. A total of 57 patients (36%) with cEGFRm received osimertinib as their first-line treatment, and 61 (39%) received it as their second-line treatment. One-year OS (95% CI) following the discontinuation of osimertinib was 35% (17, 75) post-first-line and 20% (9, 44) post-second-line. In this real-world AI-generated dataset, survival post-osimertinib was poor in patients with cEGFR mutations. Patients with ex20ins in this cohort had improved outcomes, possibly due to ex20ins targeting treatment, highlighting the need for more effective treatments for patients with advanced EGFRm NSCLC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inteligencia Artificial / Carcinoma de Pulmón de Células no Pequeñas / Receptores ErbB / Neoplasias Pulmonares / Mutación Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Curr Oncol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inteligencia Artificial / Carcinoma de Pulmón de Células no Pequeñas / Receptores ErbB / Neoplasias Pulmonares / Mutación Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Curr Oncol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza