Prognostic Factors Associated with Tumor Recurrence and Overall Survival in Soft Tissue Sarcomas of the Extremities in a Colombian Reference Cancer Center.
Curr Oncol
; 31(4): 1725-1738, 2024 03 26.
Article
en En
| MEDLINE
| ID: mdl-38668034
ABSTRACT
Introduction:
Soft tissue sarcomas (STS) are low-incidence tumors whose clinical and histopathological factors are associated with adverse oncological outcomes. This study evaluated prognostic factors (PF) associated with tumor recurrence and overall survival (OS) in patients diagnosed with STS of the extremities, treated at the Instituto Nacional de Cancerología (INC), Bogotá, Colombia. Materials andMethods:
An analytical observational study of a historical cohort was carried out, including patients diagnosed with STS and managed surgically in the Functional Unit for Breast and Soft Tissue Tumors of the INC from January 2008 to December 2018.Results:
A total of 227 patients were included; 74.5% had tumors greater than 5 cm. Most patients (29.1%) were in stage IIIB at diagnosis. Age was associated with higher mortality (HR = 1.01; CI95% 1-1.02; p = 0.048). Tumor persistence at admission to the INC (HR = 2.34; CI95% 1.25-4.35; p = 0.007) and histologic grade III (HR = 5.36; CI95% 2.29-12.56; p = <0.001) showed statistical significance in the multivariate analysis for recurrence of any type, as did the PFs associated with a higher risk of local recurrence (HR = 2.85; CI95% 1.23-6.57; p = 0.014 and HR = 6.09; CI95% 2.03-18.2; p = 0.001), respectively. Tumor size (HR = 1.03; CI95% 1-1.06; p = 0.015) and histologic grade III (HR = 4.53; CI95% 1.42-14.49; p = 0.011) were associated with a higher risk of distant recurrence.Conclusions:
This cohort showed that in addition to histologic grade and tumor size, tumor persistence at the time of admission has an impact on disease recurrence, so STS should be managed by a multidisciplinary team with experience in this pathology in high-volume reference centers.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sarcoma
/
Extremidades
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Recurrencia Local de Neoplasia
Límite:
Adult
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Aged
/
Aged80
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Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
America do sul
/
Colombia
Idioma:
En
Revista:
Curr Oncol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Colombia
Pais de publicación:
Suiza